Introduction: Magnetic resonance imaging of the breast has been heralded as a significant advance in the diagnosis of breast disease, with significantly higher sensitivity for the detection of breast cancer than either physical exam or mammography. As a result, many breast lesions are now being discovered which can only be visualized with MRI. The goal of this project is to develop imaging guidance and biopsy methods which can be used to provide pathologic diagnoses for lesions discovered on breast MRI. Three objectives have been pursued: 1. Image guidance techniques. 2. MR-guided needle localization and preoperative hookwire placement. 3. MR-guided core needle biopsy Methods: Imaging methods for guidance were developed for both closed bore 1.5T conventional magnets and the open 0.5T Signa-SP system at Stanford. Requirements for imaging include rapid scan acquisition, T1-weighting, optional fat-suppression, and minimal needle size artifacts. Short echo-train Fast Spin Echo protocols were implemented for both systems for non-fat-suppressed images At 1.5T, spectral-spatial Fast Spin Echo sequences were written and modified to include magnetization transfer. At 0.5T, 3-point Dixon gradient echo sequences were implemented, and an automated Dixon reconstruction program was developed for rapid image processing and display. MR-guided needle placement was developed using a commercially available open platform coil. Interactive techniques, similar to freehand ultrasound guided breast needle localization procedures were implemented. Procedures were tested on 20 lesions which were visible by other imaging methods, in patients going for excisional biopsy. Results: Successful imaging methods were developed for both 1.5T and 0.5T systems. To date, over 20 needle localizations have been performed with average accuracy of less than 9 mm in all cases. Core biopsy procedures require further refinement to reduce the artifacts cast by biopsy needles on Dixon images, so that they do not obscure target lesions. Conclusions: A rapid, easy, accurate and successful technique for biopsy of lesions detected on Breast MR images has been developed. Future work is in progress to develop core biopsy techniques which will supplant some of the surgical biopsies which are currently required for lesions detected by MR.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR009784-05S1
Application #
6309974
Study Section
Project Start
1999-01-01
Project End
2000-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
2000
Total Cost
$15,525
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Maclaren, Julian; Aksoy, Murat; Ooi, Melvyn B et al. (2018) Prospective motion correction using coil-mounted cameras: Cross-calibration considerations. Magn Reson Med 79:1911-1921
Guo, Jia; Holdsworth, Samantha J; Fan, Audrey P et al. (2018) Comparing accuracy and reproducibility of sequential and Hadamard-encoded multidelay pseudocontinuous arterial spin labeling for measuring cerebral blood flow and arterial transit time in healthy subjects: A simulation and in vivo study. J Magn Reson Imaging 47:1119-1132
Tamir, Jonathan I; Uecker, Martin; Chen, Weitian et al. (2017) T2 shuffling: Sharp, multicontrast, volumetric fast spin-echo imaging. Magn Reson Med 77:180-195
Lai, Lillian M; Cheng, Joseph Y; Alley, Marcus T et al. (2017) Feasibility of ferumoxytol-enhanced neonatal and young infant cardiac MRI without general anesthesia. J Magn Reson Imaging 45:1407-1418
Taviani, Valentina; Alley, Marcus T; Banerjee, Suchandrima et al. (2017) High-resolution diffusion-weighted imaging of the breast with multiband 2D radiofrequency pulses and a generalized parallel imaging reconstruction. Magn Reson Med 77:209-220
Uecker, Martin; Lustig, Michael (2017) Estimating absolute-phase maps using ESPIRiT and virtual conjugate coils. Magn Reson Med 77:1201-1207
Kogan, Feliks; Hargreaves, Brian A; Gold, Garry E (2017) Volumetric multislice gagCEST imaging of articular cartilage: Optimization and comparison with T1rho. Magn Reson Med 77:1134-1141
Aksoy, Murat; Maclaren, Julian; Bammer, Roland (2017) Prospective motion correction for 3D pseudo-continuous arterial spin labeling using an external optical tracking system. Magn Reson Imaging 39:44-52
Bian, W; Tranvinh, E; Tourdias, T et al. (2016) In Vivo 7T MR Quantitative Susceptibility Mapping Reveals Opposite Susceptibility Contrast between Cortical and White Matter Lesions in Multiple Sclerosis. AJNR Am J Neuroradiol 37:1808-1815
Vos, Sjoerd B; Aksoy, Murat; Han, Zhaoying et al. (2016) Trade-off between angular and spatial resolutions in in vivo fiber tractography. Neuroimage 129:117-132

Showing the most recent 10 out of 446 publications