This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: If an individual can learn to directly control activation of localized regions within the brain, this approach might provide control over the neurophysiological mechanisms that mediate behavior and cognition and could potentially provide a different route for treating disease. Control over the endogenous pain modulatory system is a particularly important target because it could enable a unique mechanism for clinical control over pain. Methods and Discussion: 10 (2 M: 8 F) chronic pain patients from the Stanford University Pain Management Center were trained to increase and then to decrease brain activation in the rACC target ROI using cognitive strategies. Following each 13-min run, patients made quantitative ratings of the difference in pain intensity during the increase compared to the decrease conditions. atients received 2-3 training runs/session for 6 sessions.
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