This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Memory for the past yields knowledge that can be used to satisfy current goals. When we interrogate memory, recollection of a specific (criterial) contextual detail may be required to guide present behavior, with recollection of other (non-criterial) information often being insufficient to satisfy the goal. The distinction between criterial and non-criterial recollection may be vital to understanding the contributions of specific medial temporal lobe (MTL) substructures to encoding of item and conjunctive information. The current high-resolution fMRI study used the subsequent memory paradigm to assess how MTL encoding processes support later item recognition and later recognition accompanied by varying levels of contextual recollection. During encoding, participants were scanned while they incidentally encoded visually-presented adjectives in one of four ways: generated an associated mental image of an indoor scene or outdoor scene, or generated an associated name of a famous female person or male person. A post-scan recognition memory test probed for item and conjunctive memory in a three-step procedure: (1) item recognition (old/new), (2) task recollection (scene/person), and (3) detailed recollection (indoor/outdoor or male/female). Encoding activation in MTL subregions was analyzed based on later item recognition and varying levels of context recollection.
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