This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Introduction: To identify the neural circuits of conflict processing and attentional allocation with fMRI, we devised a Stroop Match-to-Sample task requiring a decision based on a color cue that directs attention to a specific color and primes the color processing of the stimulus. Healthy right-handed adult volunteers underwent fMRI while performing the Stroop Match-to-Sample task. Subjects matched the color of a cue stimulus in the center of the screen to the color of a Stroop target stimulus. The color cue either matched or did not match the color of the Stroop target, which was either congruent (word blue written in blue ink) or incongruent (word blue written in red ink). Two runs were presented with 18 blocks per run (TR = 2.2 sec). Stroop conflict processing with pretrial color cueing (Match) was associated with BOLD signal increases in a fronto-parietal attention network involving the left ACC, STG, d- PCC and the right parietal cortex. The Match contrast (nonmatch vs. match cue-target color) was mainly associated with d-PCC activation. Conclusion: This paradigm provides a novel differentiation of frontal-parietal attention systems and lays a foundation for clinical research on identifying sources of disruption of neural systems of attention.Funding Sources' This work was supported by NIAAA grants: AA10723, AA05965Relevant publications' Pfefferbaum A, Adalsteinsson E, Sullivan EV (2006). Biol Psychiatry, 59:364-372.' Schulte T, M ller-Oehring EM, Rosenbloom MJ, Pfefferbaum A, Sullivan EV (2005). Biol Psychiatry, 57:67-75.' Schulte, T, M ller-Oehring, EM, Salo, R, Pfefferbaum, A, Sullivan, EV (2006). Neuropsychology, 20:727-736.' Sullivan EV, Pfefferbaum (2005). Psychopharmacology, 180:583-94.
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