This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.ntroductionImage-guided cryoablation is a minimally invasive therapy for renal cancer. To this end, MR parameters of frozen tissue have been measured with ultrashort TE MR imaging on a low field interventional system [1,2], but understanding of the contribution of the proton resonant frequency shift to the observed phase changes have been limited by the SNR of the frozen tissue at low field.
Aims The purpose of this study was to measure the MR parameters of frozen tissue (PRF shift and R2*) on a high field spectrometer.MethodsFreshly excised kidney samples were imaged with the Varian INOVA 300 MHz NMR system. Tissue temperature was decreased to 30 C in steps. To calculate 1H frequency shift with temperature, the baseline frequency was subtracted from the 1H frequency at every temperature. The R2* was calculated from the linewidth.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR009784-14
Application #
7722917
Study Section
Special Emphasis Panel (ZRG1-SBIB-F (40))
Project Start
2008-06-01
Project End
2009-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
14
Fiscal Year
2008
Total Cost
$5,604
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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