This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Dyslexia is a developmental condition that affects much as 17% of children (Shaywitz, 1994). In examining the neurobiology of dyslexia, voxel-based morphometry (VBM) studies have shown reduced gray matter density and volume in the left parieto-temporal and left occipito-temporal regions of dyslexic readers when compared to normal readers (Brown et al., 2001;M. A. Eckert et al., 2005;Silani et al., 2005).
Specific Aims : Using VBM, this longitudinal study will extend upon previous studies by examining the structural correlates of reading development in adolescent dyslexic readers. Methods: Twenty two adolescents with dyslexia were followed up for 2.5 years. Participants'IQ and word identification (WID) abilities were tested at baseline and follow-up. High resolution anatomical scans were collected at baseline for optimized and modulated VBM analysis. Whole brain regression analyses between local gray and white matter volumes and delta standard scores (ss) were performed, while regressing out baseline age, IQ and WID scores as nuisance variables.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR009784-15
Application #
7955380
Study Section
Special Emphasis Panel (ZRG1-SBIB-F (40))
Project Start
2009-06-01
Project End
2010-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
15
Fiscal Year
2009
Total Cost
$12,030
Indirect Cost
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305
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