D. Gibson is a professor at the Hebrew University. He became experienced with mass spectrometry during his MS degree program, and has used instrumental techniques, particularly NMR, throughout his career. During his current sabbatical at the Resource, he will update his earlier experience by carrying out projects that require MALDI and ESI, both in areas related to his own research interests, the interactions of anticancer agents with oligonucleotides, and in collaborations with Resource and external personnel. Upon his return to Israel, his institution is planning to purchase both MALDI and ESI mass spectrometers, and Prof. Gibson will assume responsibility for oversight of these new instruments. N. Kelleher received his PhD at Cornell University under the direction of F. W. McLafferty and T. Begley. His thesis project centered on determinations of properties of proteins using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. He is presently a postdoctoral fellow in the research group of C. T. Walsh at Harvard Medical School. In order to broaden his experience with a variety of mass spectral techniques, Dr. Kelleher is now undertaking experiments that involve electrospray ionization triple quadrupole tandem mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, under the guidance of Resource staff.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR010888-05S1
Application #
6478989
Study Section
Project Start
2000-07-01
Project End
2002-06-30
Budget Start
Budget End
Support Year
5
Fiscal Year
2001
Total Cost
$53,566
Indirect Cost
Name
Boston University
Department
Type
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Lu, Yanyan; Jiang, Yan; Prokaeva, Tatiana et al. (2017) Oxidative Post-Translational Modifications of an Amyloidogenic Immunoglobulin Light Chain Protein. Int J Mass Spectrom 416:71-79
Sethi, Manveen K; Zaia, Joseph (2017) Extracellular matrix proteomics in schizophrenia and Alzheimer's disease. Anal Bioanal Chem 409:379-394
Hu, Han; Khatri, Kshitij; Zaia, Joseph (2017) Algorithms and design strategies towards automated glycoproteomics analysis. Mass Spectrom Rev 36:475-498
Ji, Yuhuan; Bachschmid, Markus M; Costello, Catherine E et al. (2016) S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom 27:677-85
Hu, Han; Khatri, Kshitij; Klein, Joshua et al. (2016) A review of methods for interpretation of glycopeptide tandem mass spectral data. Glycoconj J 33:285-96
Pu, Yi; Ridgeway, Mark E; Glaskin, Rebecca S et al. (2016) Separation and Identification of Isomeric Glycans by Selected Accumulation-Trapped Ion Mobility Spectrometry-Electron Activated Dissociation Tandem Mass Spectrometry. Anal Chem 88:3440-3
Wang, Yun Hwa Walter; Meyer, Rosana D; Bondzie, Philip A et al. (2016) IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function. J Mol Biol 428:5019-5033
Steinhorn, Benjamin S; Loscalzo, Joseph; Michel, Thomas (2015) Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. N Engl J Med 373:277-80
Walsh, Erica M; Niu, MengMeng; Bergholz, Johann et al. (2015) Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation. Biochem Biophys Res Commun 461:293-9
Théberge, Roger; Dikler, Sergei; Heckendorf, Christian et al. (2015) MALDI-ISD Mass Spectrometry Analysis of Hemoglobin Variants: a Top-Down Approach to the Characterization of Hemoglobinopathies. J Am Soc Mass Spectrom 26:1299-310

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