This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The BUSM MS Resource sponsors a weekly seminar series open to all interested persons in the Medical School community as well as investigators from other academic, research and industrial institutions throughout the Boston area. These provide an opportunity for staff members to present summaries of their ongoing research and for visiting scientists to meet and discuss their research with local scientists. Resource faculty also invite outstanding mass spectrometrists and other collaborators to present seminars in the Dept. of Biochemistry. Publicity for these both types of seminars takes the form of posted notices, as well as standard mail, e-mail and telephone announcements to those within and outside BUSM. Included among this reporting year's visiting speakers were Prof. Barbara Kahn, Beth Israel Hospital, Boston, Prof. Igor Kaltashov, Univ. Massachusetts, Amherst, Prof. Byung Gee Kim, Seoul National University, Prof. Julie Leary, Univ. California, Davis, Prof. Wayne Lencer, Children's Hospital, Boston, Prof. Robert Sackstein, Harvard Medical School, Prof. Pierre Thibault, Univ. of Montreal, Prof. Wilhelm von der Leith, Univ. Giessen, Dr. Ling Xu, University of Toronto, Dr. Stephen Shi, Rutgers University, and Dr. Chunxiang Yao, Univ. of Washington.In her role as Director of the NHLBI-funded BUSM Cardiovascular Proteomics Center (CPC), Prof. Costello was the co-organizer of a symposium on Oxidative Post-translational Modifications in the Cardiovascular System that was held at BUSM , October 3-6, 2006. This meeting, the second in a biennial series that is being sponsored by the CPC, attracted about 150 investigators and students from around and outside the US. Participants had the opportunity to visit the MS Resource and to receive advice from staff members. In addition to BUSM staff and students, many active mass spectrometrists were among the invited speakers and attendees, including Prof. Bruce Freeman, Univ. of Pittsburgh School of Medicine, Prof. Bradford gibson, Buck Institute for Age Research, Prof. Michael Przybylski, Univ. of Konstanz, and Prof. Joseph Loscalzo, Harvard Medical School. An R13 grant was obtained to help provide funding for the second meeting in October 2006 and the third in October 2008. In conjunction with the Symposium, a tutorial workshop that includes both lecture and laboratory sessions was held on the day preceding the main meeting. Resource personnel assisted in the presentation of workshop lectures and tours.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR010888-11
Application #
7601987
Study Section
Special Emphasis Panel (ZRG1-BCMB-H (40))
Project Start
2007-08-03
Project End
2008-05-31
Budget Start
2007-08-03
Budget End
2008-05-31
Support Year
11
Fiscal Year
2007
Total Cost
$10,774
Indirect Cost
Name
Boston University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Lu, Yanyan; Jiang, Yan; Prokaeva, Tatiana et al. (2017) Oxidative Post-Translational Modifications of an Amyloidogenic Immunoglobulin Light Chain Protein. Int J Mass Spectrom 416:71-79
Sethi, Manveen K; Zaia, Joseph (2017) Extracellular matrix proteomics in schizophrenia and Alzheimer's disease. Anal Bioanal Chem 409:379-394
Hu, Han; Khatri, Kshitij; Zaia, Joseph (2017) Algorithms and design strategies towards automated glycoproteomics analysis. Mass Spectrom Rev 36:475-498
Ji, Yuhuan; Bachschmid, Markus M; Costello, Catherine E et al. (2016) S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom 27:677-85
Hu, Han; Khatri, Kshitij; Klein, Joshua et al. (2016) A review of methods for interpretation of glycopeptide tandem mass spectral data. Glycoconj J 33:285-96
Pu, Yi; Ridgeway, Mark E; Glaskin, Rebecca S et al. (2016) Separation and Identification of Isomeric Glycans by Selected Accumulation-Trapped Ion Mobility Spectrometry-Electron Activated Dissociation Tandem Mass Spectrometry. Anal Chem 88:3440-3
Wang, Yun Hwa Walter; Meyer, Rosana D; Bondzie, Philip A et al. (2016) IGPR-1 Is Required for Endothelial Cell-Cell Adhesion and Barrier Function. J Mol Biol 428:5019-5033
Srinivasan, Srimathi; Chitalia, Vipul; Meyer, Rosana D et al. (2015) Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis 18:449-62
Yu, Xiang; Sargaeva, Nadezda P; Thompson, Christopher J et al. (2015) In-Source Decay Characterization of Isoaspartate and ?-Peptides. Int J Mass Spectrom 390:101-109
Steinhorn, Benjamin S; Loscalzo, Joseph; Michel, Thomas (2015) Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. N Engl J Med 373:277-80

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