BOLD imaging has been used to monitor oxygenation in brain by capitalizing on the fact that deoxyhemoglobin has a paramagnetic susceptability and so changes in deoxyhemoglobin content can be visualized using MR imaging. This phenomenon forms the core of the field of cognative, or functional MR imaging. In addition, this measurement provides a rapid, spatially selective method of assessing the brain's response to acute hypoxia. We are investigating the relationships between changes in deoxyhemoglobin using BOLD imaging and brain pO2 using EPR oximetry. The relationships between tissue pO2 values and averaged hemoglobin saturation are not easily predicted and must be measured. With the combination of """"""""non-invasive"""""""" EPR oximetry and MR imaging, we hope to calibrate the BOLD response in living brain, determine the regional senstivity of brain to functional imaging and identify spatial heterogeneity in the brain's response to acute hypoxia.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR011602-04
Application #
6206506
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
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