Miniature very high frequency transducers are needed for imaging and measuring blood flow in the heart of a mouse embryo for a better understanding of the development of congenital heart diseases in the fetus in utero. The current trend is towards earlier in utero diagnosis and management of congenital heart diseases in the fetus. This has been made possible by the improvement in image quality of ultrasonic scanners in past few years. VHF transducers have to be used here because of the small size of the mouse heart. Focused PVDF transducers at 40 MHz have been used in an Ultrasonic Backscatter Microscopy (UBM) to obtain B-mode images of mouse embryos. The current goal is to increase the frequency to beyond 50 MHz and to increase the frame rate of the UBM to the extent that it allows for the imaging of the beating embryonic heart. The UBM system will be augmented with 50 MHz Doppler probes that can be used to measure blood flow characteristics and heart functions in the early embryonic heart. Transducers using a modified lead titanate (PT) which has a lower dielectric constant (220) than PZT at 50 MHz with a 3.5 f number, 65 MHz with a 2.4 f number, and 95 MHz with a 2.4 f number have been built and tested at NYU. Linear and annular arrays with tighter focusing and higher frame rate being developed at the Resource are better suited for this application. A 50 MHz annular array is being designed and developed and will be evaluated at NYU once it is completed. ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR011795-03
Application #
6206566
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Type
DUNS #
City
University Park
State
PA
Country
United States
Zip Code
16802
Reddy, Anilkumar K; Hartley, Craig J; Pham, Thuy T et al. (2014) Young little mice express a premature cardiovascular aging phenotype. J Gerontol A Biol Sci Med Sci 69:152-9
Gurha, Priyatansh; Wang, Tiannan; Larimore, Ashley H et al. (2013) microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One 8:e75882
Crossland, Randy F; Durgan, David J; Lloyd, Eric E et al. (2013) A new rodent model for obstructive sleep apnea: effects on ATP-mediated dilations in cerebral arteries. Am J Physiol Regul Integr Comp Physiol 305:R334-42
Nagamani, Sandesh C S; Campeau, Philippe M; Shchelochkov, Oleg A et al. (2012) Nitric-oxide supplementation for treatment of long-term complications in argininosuccinic aciduria. Am J Hum Genet 90:836-46
Lee, Hyeong Jae; Zhang, Shujun (2012) Design of low-loss 1-3 piezoelectric composites for high-power transducer applications. IEEE Trans Ultrason Ferroelectr Freq Control 59:1969-75
Lloyd, Eric E; Crossland, Randy F; Phillips, Sharon C et al. (2011) Disruption of K(2P)6.1 produces vascular dysfunction and hypertension in mice. Hypertension 58:672-8
Hartley, Craig J; Reddy, Anilkumar K; Madala, Sridhar et al. (2011) Doppler velocity measurements from large and small arteries of mice. Am J Physiol Heart Circ Physiol 301:H269-78
Chintalgattu, Vishnu; Ai, Di; Langley, Robert R et al. (2010) Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest 120:472-84
Song, Liang; Maslov, Konstantin; Shung, K Kirk et al. (2010) Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo. J Biomed Opt 15:021303
Zhang, Shujun; Sherlock, Nevin P; Meyer, Richard J et al. (2009) Crystallographic dependence of loss in domain engineered relaxor-PT single crystals. Appl Phys Lett 94:162906

Showing the most recent 10 out of 24 publications