Abstract

During myocardial ischemia, oxidative metabolism is reduced and fatty acids and triglycerides accumulate within the myocardial cell. The fatty acids and related substances, such as fatty acylcarnitines, are amphophilic and can lead to cell membrane destruction. Magnetic resonance methods can assess the concentration of lipids (generally triglycerides) within the myocardium. The observation of lipids within the myocardium is postulated to indicate viability. Various pharmacological interventions are used to evaluate their effect on myocardial lipid accumulation in control and during myocardial ischemic insults. Surface coils placed on the epicardium are used to interrogate the myocardial lipid content in a 4.7T Bruker Biospec 40cm bore system in canine models. It is anticipated that in the last years of this RO1, patients with MI, both reperfused and non-reperfused, will be studied in the 4.1T MR system to determine the relationship between myocardial lipid content and high energy phosphate metabolism.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR011811-05
Application #
6480893
Study Section
Project Start
2001-08-01
Project End
2003-02-28
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
5
Fiscal Year
2001
Total Cost
$155,764
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Sirikul, Bovorn; Hunter, Gary R; Larson-Meyer, D Enette et al. (2007) Relationship between metabolic function and skeletal muscle fatigue during a 90 s maximal isometric contraction. Appl Physiol Nutr Metab 32:394-9
Redden, David T; Divers, Jasmin; Vaughan, Laura Kelly et al. (2006) Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model. PLoS Genet 2:e137
Elgavish, Rotem A; Twieg, Donald B (2003) Improved depiction of small anatomic structures in MR images using Gaussian-weighted spirals and zero-filled interpolation. Magn Reson Imaging 21:103-12
Twieg, Donald B (2003) Parsing local signal evolution directly from a single-shot MRI signal: a new approach for fMRI. Magn Reson Med 50:1043-52
Larson-Meyer, D Enette; Newcomer, Bradley R; Hunter, Gary R (2002) Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study. Am J Physiol Endocrinol Metab 282:E95-E106
Newcomer, B R; Larson-Meyer, D E; Hunter, G R et al. (2001) Skeletal muscle metabolism in overweight and post-overweight women: an isometric exercise study using (31)P magnetic resonance spectroscopy. Int J Obes Relat Metab Disord 25:1309-15
Newman, S D; Twieg, D B; Carpenter, P A (2001) Baseline conditions and subtractive logic in neuroimaging. Hum Brain Mapp 14:228-35
Newman, S D; Twieg, D (2001) Differences in auditory processing of words and pseudowords: an fMRI study. Hum Brain Mapp 14:39-47
Patton, H K; Chu, W J; Hetherington, H P et al. (2001) Alkaline pH changes in the cerebellum of asymptomatic HIV-infected individuals. NMR Biomed 14:12-8
Larson-Meyer, D E; Newcomer, B R; Hunter, G R et al. (2001) Relation between in vivo and in vitro measurements of skeletal muscle oxidative metabolism. Muscle Nerve 24:1665-76

Showing the most recent 10 out of 19 publications