This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Use of the most sensitive fold recognition algorithms available leaves about 5000 of the previously predicted 12,000 structural domains in yeast without structural information. The goal of this project is to subject these putative domains to the Rosetta algorithm. This is the first attempt to structurally characterize an entire eukaryotic genome using fold-recognition and de novo methods.
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