This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. LATS (large tumor suppressor) is a tumor suppressor protein originally identified in a screen for genes whose inactivation leads to overproliferation of cells in Drosophila. Two homologs of LATS have been identified in mammals (LATS1, LATS2). Inactivation of LATS2 in mice leads to embryonic lethality, and fibroblast cells from the embryo shows high rate of aneuploidy, suggesting that LATS functions as a tumor suppressor and plays a role in proper M-phase progression. At the molecular level, the function of LATS is not well understood. To elucidate that, we are trying to identify the proteins associate with LATS as candidates for possible target (substrate) or regulator of this kinase.
Showing the most recent 10 out of 583 publications