This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Residue specific methylation of histones results in diverse epigenetic states. But how histone methyltransferase (enzymes that add methyl group to histones) are targeted to specific chromosome domains are not well understood. More importantly, apart from several well-known examples, how the cellular machinery recognizes these modifications is not clear. Our previous purification of H3K9 methyltransferase uncovered a surprising link between protein ubiquitylation and RNAi mediated heterochromatin assembly. I plan to purify histone methyltransferase complexes to identify novel proteins that regulate histone methylation.
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