This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.During nerve cell development, postmitotic neurons transform from seemingly unpolarized cells into highly polarized ones. These highly polarized neurons contain long cellular processes termed neurites that are filled with the microtubule (MT) cytoskeleton, and will later mature into axons or dendrites. It has been shown that the morphological change during neuronal development depends on the organization of the MT cytoskeleton. Although many of MT-associated proteins are known to play important roles during neuronal morphogenesis, a comprehensive proteomic analysis focusing on the MT cytoskeleton during this process is lacking. To better understand the mechanisms controlling neurite formation, we propose to perform MS-based proteomic analysis on MT-associated proteins before and during this process.
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