This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The proper functioning of any living cell requires that approximately half of all proteins synthesized in the cytosol must be translocated across (in the case of soluble proteins) or inserted into (in the case of membrane proteins) a cell membrane. Protein translocation at the membrane occurs through a proteinaceous channel, termed the translocon or translocase. The core of the translocon, the protein-conducting channel (PCC), is heterotrimeric integral membrane protein complex (SecY in eubacteria/archaea, Sec61 in eukaryotes) composed of the following: the gamma-subunit (SecY in eubacteria/archaea, Sec61g in mammals), the gamma-subunit (SecG in eubacteria, Sec? in archaea, Sec61g in mammals) and the g-subunit (SecE in eubacteria/archaea, Sec61g in mammals).

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Biotechnology Resource Grants (P41)
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Special Emphasis Panel (ZRG1-BCMB-E (40))
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Scripps Research Institute
La Jolla
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