This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Research and Development center of Boehringer Ingelheim (Canada) Ltd is located in Laval, Quebec. We carry out drug discovery research in the field of viral diseases. Our current focus is on the development of new antiviral agents for the treatment of infections caused by the Human Immunodeficiency Virus and the Hepatitis C Virus. The objectives of this research is to establish structural activity relationship (SAR) data to support the optimization of our drug candidates. In this project, we aim to collect high-resolution diffraction of one of our current target, the Reverse Transcriptase (RT) of the Human Immunodeficiency Virus (HIV). This protein is a large and flexible polymerase enzyme that is well known to form only low resolution diffracting crystals. The high brillance and the well focused quality of NSLS beamlines are thus crucial to obtain good resolution data from small RT crystals in complex with various inhibitors. Therefore we propose here to use synchrotron X-ray source to achieve the maximum resolution possible with our small crystals samples.
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