This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Our research focuses on studying how HIV buds from cells by utilizing cellular machinery normally used in the formation of luminal vesicles of late endosomes. Several proteins in this pathway are required for the budding of several retroviruses, including HIV. One protein in this pathway is AIP1, which binds directly to both HIV and EIAV through a PPXY late domain found in the virus. It is also believed that AIP1 plays an important role in membrane bending events since AIP1 binds to specific lipids found in the late endosome, in addition to binding to proteins which are also believed to function in membrane bending. Structural information on AIP1 and its binding partners will provide insight into how AIP1 binds viruses and how AIP1 could function in bending membranes, both of which are critical for viruses to properly bud from the cell.
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