This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A simple mathematical model of Cdc2-cyclin B activation during the cell cycle G2/M transition has been studied both deterministically and stochastically. Currently, the switch-like behavior of the system in this case is explained based on the possible bistability of the underlying signaling network. In this project, we have shown that the bistability of a biochemical pathway might not be sufficient for withstanding parameter variability and intrinsic noise. Robustness of bio-switching in this case can be enhanced significantly if the instability in the signaling network is coupled with the phase change in the macro-subsystem with non-local interactions such as aggregates observed in immature starfish oocytes.
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