This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is a major need for a well-documented, comprehensive collection of software tools for heart rate variability analysis. We are addressing this need by developing and posting a heart rate variability 'toolkit' which will supplement the tools already available at www.physionet.org. These tools will include software for the extraction of RR/NN interval time series, the filtering of outliers and software for both time domain and frequency domain analysis. Tools for time domain analysis will calculate the traditional measures of AVNN, SDNN, SDANN index, SDNN index, rMSSD and pNN50. Tools for frequency domain analysis will include programs for linear and cubic spline resampling, standard FFT analysis as well as the Lomb periodogram for unevenly sampled data. Included will be utilities for calculating the spectral power in the very low frequency, low frequency, and high frequency power bands and the calculation of low frequency to high frequency ratio and log-log power slopes. We will also include newer techniques based on nonlinear dynamics and fractal analysis. In addition to these utilities, there will also be available programs for the plotting of the results of these calculations and general utilities for curve fitting, the calculation of statistics and various data manipulation tools. This 'toolkit' will be accompanied by a tutorial covering the correct application of these programs.
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