1. Perform a clinical trial with divalproex sodium, consisting of an open phase followed by double blind discontinuation in children and adolescents with BD. hypothesis: Divalproex sodium will show safety and efficacy in symptom response as measured by the Clinical Global Impressions Scale (CGI) and the Young/Fristad Mania Scale after 8 weeks of monotherapy in a group of children and adolescents diagnosed with bipolar illness. 2. Identify potential predictors of treatment response. hypothesis: There will be a significant correlation between change in cerebral GA13A concentration as measured by Magnetic Resonance Spectroscopy (IHMRS), and change in treatment response to divalproex sodium as measured by the CGI after two weeks of therapy. We hypothesize that a higher cerebral GABA concentration will be significantly related to a decrease in symptom response to divalproex sodium.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR013642-03
Application #
6346402
Study Section
Project Start
2000-08-01
Project End
2001-07-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
3
Fiscal Year
2000
Total Cost
$7,687
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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