Our proposed neuroimaging Resource for multi-dimensional modeling will go beyond current atlases and maps of brain that assume a static morphology and prohibit the examination of time varying changes. We will develop the framework and tools to rigorously evaluate dynamic changes in brain structure and function focusing particularly on processes such as development, aging and the progression of specific diseases. We have identified four areas of research that are of critical importance: Surface Parameterization, Volume Parameterization, Anatomical Fundamentals and Visualization of Animation. Each of these complements the other to form an integrated and comprehensive research program. The unique focus on multi- dimensional modeling is in contrast to many other neuroimaging centers where the focus is on image acquisition. Our plans include collaborations with a diverse and well funded group of basic, applied and clinical scientists working on neuroscientific problems and health and disease. These projects were selected on the basis of their mutually beneficial, symbiotic relationship with our core research plans and the specific aims of their funded projects. Plans are provided for service to other investigators in the form of robust software access to computer hardware resources and distribution of unique data sets. We will disseminate information about our Resource by publication, electronic media and the creation of video animations of our results. Training opportunities for students and colleagues will be available on site or remotely and will include hands-on experiences, prepared material, workshops, and interactive electronic presentations. 7 An administrative structure and national recognized advisory board will be created to manage the responsibilities of the Resource. Our plans for this Resource build upon an extensive history of research in image analysis, morphometric variability, brain mapping and visualization. This, coupled with our NCRR pre-resource experience, position us perfectly to created and direct an outstanding Resource.
| Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139 |
| Yang, Yaling; Joshi, Shantanu H; Jahanshad, Neda et al. (2017) Neural correlates of proactive and reactive aggression in adolescent twins. Aggress Behav 43:230-240 |
| Dennis, Emily L; Rashid, Faisal; Faskowitz, Josh et al. (2017) MAPPING AGE EFFECTS ALONG FIBER TRACTS IN YOUNG ADULTS. Proc IEEE Int Symp Biomed Imaging 2017:101-104 |
| Walsh, Christine M; Ruoff, Leslie; Walker, Kathleen et al. (2017) Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy. Sleep 40: |
| Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2017) Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Res 10:801-809 |
| Agis, Daniel; Goggins, Maria B; Oishi, Kumiko et al. (2016) Picturing the Size and Site of Stroke With an Expanded National Institutes of Health Stroke Scale. Stroke 47:1459-65 |
| Levine, Andrew J; Soontornniyomkij, Virawudh; Achim, Cristian L et al. (2016) Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV. J Neurovirol 22:431-41 |
| Flournoy, John C; Pfeifer, Jennifer H; Moore, William E et al. (2016) Neural Reactivity to Emotional Faces May Mediate the Relationship Between Childhood Empathy and Adolescent Prosocial Behavior. Child Dev 87:1691-1702 |
| Joshi, Shantanu H; Vizueta, Nathalie; Foland-Ross, Lara et al. (2016) Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 1:507-517 |
| Ordóñez, Anna E; Loeb, Frances F; Zhou, Xueping et al. (2016) Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. J Am Acad Child Adolesc Psychiatry 55:792-9 |
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