This project is a family genetic stud), comparing childhood onset schizophrenia and attention deficit hyperactivity disorder. The objective of this study is to identify genes associated with different facets of the schizophrenia phenotype.
Specific Aims 1. To determine the rate of schizophrenia and Schizophrenic Spectrum Personality Disorder (SSPD) by direct interviews of first degree relatives, and by family history for second degree relatives, of children with onset of schizophrenia prior to thirteen years of age. To compare the rates of schizophrenia and SSPD among the first and second degree relatives of schizophrenic children to those observed in children with ADHD and normal control children. 2. To test the hypothesis that certain attention and information processing (AIP) Impairments index a genetic liability to schizophrenic disorder by determining if there is an increased aggregation of certain impairments among the first degree relatives of schizophrenic children as compared to the first degree relatives of children with ADHD and normal control children. 3. To replicate findings that schizophrenic probands have reduced total cerebral volume and reductions in the volume of the midsagittal thalamic area which exceeds the reduction in total cerebral volume, and enlargements of the caudate and putamen. 4. To identify genes associated with the presence of schizophrenia, SSPD, AIP. impairments and changes in volumes of brain structures in schizophrenic probands and their siblings.
| Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139 |
| Yang, Yaling; Joshi, Shantanu H; Jahanshad, Neda et al. (2017) Neural correlates of proactive and reactive aggression in adolescent twins. Aggress Behav 43:230-240 |
| Dennis, Emily L; Rashid, Faisal; Faskowitz, Josh et al. (2017) MAPPING AGE EFFECTS ALONG FIBER TRACTS IN YOUNG ADULTS. Proc IEEE Int Symp Biomed Imaging 2017:101-104 |
| Walsh, Christine M; Ruoff, Leslie; Walker, Kathleen et al. (2017) Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy. Sleep 40: |
| Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2017) Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Res 10:801-809 |
| Flournoy, John C; Pfeifer, Jennifer H; Moore, William E et al. (2016) Neural Reactivity to Emotional Faces May Mediate the Relationship Between Childhood Empathy and Adolescent Prosocial Behavior. Child Dev 87:1691-1702 |
| Joshi, Shantanu H; Vizueta, Nathalie; Foland-Ross, Lara et al. (2016) Relationships Between Altered Functional Magnetic Resonance Imaging Activation and Cortical Thickness in Patients With Euthymic Bipolar I Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 1:507-517 |
| Ordóñez, Anna E; Loeb, Frances F; Zhou, Xueping et al. (2016) Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. J Am Acad Child Adolesc Psychiatry 55:792-9 |
| Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2016) Salience Network Connectivity in Autism Is Related to Brain and Behavioral Markers of Sensory Overresponsivity. J Am Acad Child Adolesc Psychiatry 55:618-626.e1 |
| Kodumuri, Nishanth; Sebastian, Rajani; Davis, Cameron et al. (2016) The association of insular stroke with lesion volume. Neuroimage Clin 11:41-45 |
Showing the most recent 10 out of 554 publications
