Specific Aims 1. To use MR technology to study neurodevelopmental abnormalities in schizophrenia, as revealed through gyrification patterns and the presence of abnormalities in midline structures such as the thalamus 2. To extend our work defining and quantifying surface anatomy to the development of """"""""flat maps"""""""" that will provide additional measures of surface complexity 3. To examine hypothesized anatomic substrates of cognitive dysmetria by measuring specific nodes on the CCTCC (e.g.. areas of prefrontal cortex, cerebellum. and thalamus) 4. To develop methods to parcellate and measure structural characteristics of the prefrontal cortex, using indices of sulca/gyral anatomy thus far developed 5. To develop methods to measure structural characteristics of the cerebellum (including both deep nuclei and surface anatomy) using MR 6. To apply the technique of neural networks to develop reliable and automated measures of neural structures relevant to schizophrenia 7. To examine the relationship between CCTCC abnormalities, symptom patterns, and cognitive performance

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
3P41RR013642-04S2
Application #
6505278
Study Section
Project Start
2001-08-01
Project End
2002-07-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Green, Shulamite A; Hernandez, Leanna M; Bowman, Hilary C et al. (2018) Sensory over-responsivity and social cognition in ASD: Effects of aversive sensory stimuli and attentional modulation on neural responses to social cues. Dev Cogn Neurosci 29:127-139
Yang, Yaling; Joshi, Shantanu H; Jahanshad, Neda et al. (2017) Neural correlates of proactive and reactive aggression in adolescent twins. Aggress Behav 43:230-240
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Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2017) Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD. Autism Res 10:801-809
Ordóñez, Anna E; Loeb, Frances F; Zhou, Xueping et al. (2016) Lack of Gender-Related Differences in Childhood-Onset Schizophrenia. J Am Acad Child Adolesc Psychiatry 55:792-9
Green, Shulamite A; Hernandez, Leanna; Bookheimer, Susan Y et al. (2016) Salience Network Connectivity in Autism Is Related to Brain and Behavioral Markers of Sensory Overresponsivity. J Am Acad Child Adolesc Psychiatry 55:618-626.e1
Kodumuri, Nishanth; Sebastian, Rajani; Davis, Cameron et al. (2016) The association of insular stroke with lesion volume. Neuroimage Clin 11:41-45
Kamins, Joshua; Giza, Christopher C (2016) Concussion-Mild Traumatic Brain Injury: Recoverable Injury with Potential for Serious Sequelae. Neurosurg Clin N Am 27:441-52
Agis, Daniel; Goggins, Maria B; Oishi, Kumiko et al. (2016) Picturing the Size and Site of Stroke With an Expanded National Institutes of Health Stroke Scale. Stroke 47:1459-65

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