This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This proposal will provide intercenter reliability, sensitivity, and specificity on imaging assessment of hippocampal atrophy in 30 patients with mild cognitive impairment (MCI) [15 of which are known to have incipient AD based upon longitudinal follow-up] compared to 30 elderly controls. Four imaging techniques will be assessed on a common data set derived from multiple centers across the country. These four techniques have been chosen based upon their demonstrated usefulness in evaluating medial temporal atrophy. These include: 1. The volumetric assessment technique of the Mayo group. 2. The qualitative assessment of medial temporal lobe atrophy performed by the NYU group. 3. The linear assessment technique of Jobst et al. 4. The three-dimensional mapping technique employed at UCLA. The centers participating in this multisite protocol who share common definitions of MCI and common MRI acquisition sequences are: 1. The UCLA ADRC and Laboratory of Neuro Imaging 2. The Mayo Clinic ADRC and Department of Radiology 3. The NYU ADRC and Department of Radiology Specific aims: (1) Obtain inter-center reliability data on these four techniques using a common shared database of scans obtained on both control and MCI patients. (2) Obtain sensitivity and specificity data on these four assessment techniques across centers in the identification of MCI vs. control subjects; [and the 15 incipient AD subjects within the MCI cohort] (3) Using the center-wide normative control data derived from this study, with its data on hippocampal volumetric variability, provide web-based tools to assess future patients with MCI using the most efficient and clinically useful technique identified in specific aim #2. This web-based tool will be made available to any clinic or center via the Internet and will be platform independent to allow assessment of any given subject's risk for incipient AD based up on the shared resources of imaging and clinical data derived from this present proposal.
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