Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In vivo MRI-derived measurements of human cerebral cortex thickness are providing novel insights into normal and abnormal neuroanatomy, but little is known about their reliability. The purpose of this work was to evaluate the reliability (precision) of an automated thickness measurement method both within and across scanner platforms and field strengths. We also evaluated the effects of different imaging acquisition protocols (including number of acquisitions and imaging sequences) and different data processing or post processing (smoothing of thickness map) schemes on thickness measurement reliability. Finally, we investigated the impact of scanner upgrade on thickness measurement reproducibility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR014075-08
Application #
7355851
Study Section
Special Emphasis Panel (ZRG1-SSS-X (40))
Project Start
2006-09-01
Project End
2007-08-31
Budget Start
2006-09-01
Budget End
2007-08-31
Support Year
8
Fiscal Year
2006
Total Cost
$105,054
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Hari, Riitta; Baillet, Sylvain; Barnes, Gareth et al. (2018) IFCN-endorsed practical guidelines for clinical magnetoencephalography (MEG). Clin Neurophysiol 129:1720-1747
Van de Bittner, Genevieve C; Van de Bittner, Kyle C; Wey, Hsiao-Ying et al. (2018) Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A. ACS Chem Neurosci 9:358-368
Rivas-Grajales, Ana María; Sawyer, Kayle S; Karmacharya, Sarina et al. (2018) Sexually dimorphic structural abnormalities in major connections of the medial forebrain bundle in alcoholism. Neuroimage Clin 19:98-105
Kline, Emily R; Seidman, Larry J; Cornblatt, Barbara A et al. (2018) Depression and clinical high-risk states: Baseline presentation of depressed vs. non-depressed participants in the NAPLS-2 cohort. Schizophr Res 192:357-363
Rosas, H D; Wilkens, P; Salat, D H et al. (2018) Complex spatial and temporally defined myelin and axonal degeneration in Huntington disease. Neuroimage Clin 20:236-242
Strebl, Martin G; Yang, Jane; Isaacs, Lyle et al. (2018) Adamantane/Cucurbituril: A Potential Pretargeted Imaging Strategy in Immuno-PET. Mol Imaging 17:1536012118799838
Esch, Lorenz; Sun, Limin; Klüber, Viktor et al. (2018) MNE Scan: Software for real-time processing of electrophysiological data. J Neurosci Methods 303:55-67
Zaretskaya, Natalia; Fischl, Bruce; Reuter, Martin et al. (2018) Advantages of cortical surface reconstruction using submillimeter 7 T MEMPRAGE. Neuroimage 165:11-26
Lee, Jeungchan; Mawla, Ishtiaq; Kim, Jieun et al. (2018) Machine learning-based prediction of clinical pain using multimodal neuroimaging and autonomic metrics. Pain :
Ina Ly, K; Vakulenko-Lagun, Bella; Emblem, Kyrre E et al. (2018) Probing tumor microenvironment in patients with newly diagnosed glioblastoma during chemoradiation and adjuvant temozolomide with functional MRI. Sci Rep 8:17062

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