This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project focuses on children born preterm with cerebral palsy.
The aim of this study is to investigate: (1) variations in cerebral WM injury across motor and sensory tracts and (2) relationships between specific WM abnormalities and associated motor and sensory function. The following hypotheses will be tested: 1. Upon Diffusion Tensor Imaging (DTI), there will be variation across tracts-sensory, motor, and mixed- in WM injury not detected by conventional anatomical imaging techniques. To test this hypothesis, we will quantify WM injury using volumetric analysis of brain MRI data, identify and grade the severity of WM injury in 25 tracts using DTI data and compare measures of WM injury obtained using MRI and DTI techniques. We will also classify the global distribution of WM injury within sensory and motor pathways. 2. Specific WM tract abnormalities will correlate with standardized motor and sensory test outcomes in children with cerebral palsy born preterm. Specific WM structure injury identified via conventional volumetric studies and DTI imaging classification will be correlated with standardized assessments of associated motor (strength, spasticity and dystonia) and sensory (vibration threshold) function.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR015241-09
Application #
7957326
Study Section
Special Emphasis Panel (ZRG1-SBIB-K (40))
Project Start
2009-09-01
Project End
2010-08-31
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
9
Fiscal Year
2009
Total Cost
$32,050
Indirect Cost
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
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