This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The discovery and development of new anti-infective drugs is urgently needed, as drug-resistant bacterial and viral diseases become an increasingly serious world health problem. The bacterial ribosome is a primary target of aminoglycoside antibiotics designed to combat bacterial infection. For instance, antibiotics such as paromomycin and tobramycin bind to the RNA aminoacyl decoding site (A-site) within the 16S ribosomal subunit and interfere with translation by inducing miscoding during the protein synthesis, which in turn leads to the death of the bacterial cell. The detailed high-resolution crystal structures of the A-site RNA and other bacterial ribosomal RNA drug targets will allow the elucidation of the interactions between the RNA target and these antibiotics, and will facilitate the structure-based design of novel antibiotics.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
2P41RR015301-06A1
Application #
7721266
Study Section
Special Emphasis Panel (ZRG1-BCMB-K (40))
Project Start
2008-05-15
Project End
2009-03-31
Budget Start
2008-05-15
Budget End
2009-03-31
Support Year
6
Fiscal Year
2008
Total Cost
$21,179
Indirect Cost
Name
Cornell University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
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