This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The trend at third generation synchrotron macromolecular crystallographic beam lines is towards use of progressively smaller (<50 micron) crystals of objects of increasing complexity (e.g. multienzyme complexes, biomolecular machines like the ribosome). Both trends depend upon development of technologies for extremely stable, high brilliance x-ray optics, high speed data collection, and minimization background (noise) in diffraction measurements from weakly diffracting samples. Additionally, since any given user has very limited access to our facilities, we have a strong imperative for maximizing the efficiency of our beam lines. Core 2 attempts to develop specific technologies and methods to answer these problems. Efforts in our Core 2 goals have focused on the following: 1) Continued development of our beam stabilization methodologies. 2) Improvements in the flexibility and calibration of our detector configuration systems. 3) Installation of a sample robotic loader on 24-ID-C (discussed in SPID 0099).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR015301-08
Application #
8169271
Study Section
Special Emphasis Panel (ZRG1-BCMB-K (40))
Project Start
2010-04-01
Project End
2011-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
8
Fiscal Year
2010
Total Cost
$5,795
Indirect Cost
Name
Cornell University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
872612445
City
Ithaca
State
NY
Country
United States
Zip Code
14850
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