This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies continue exploring the fundamental origins of MR signals in tissues by using a variety of models ranging from perfused isolated tissue (brain and heart) slices through isolated single cells and blood cell ghosts. The goal is to determine the origins of multiexponential water diffusion observed in tissues in the anticipation that this information can lead to a quantitative understanding of signals changes in clinical MRI. Modeling the signal characteristics in diffusion measurements in neural tissues continues. More recently we have begun to examine the effects of fixatives on these measurements, since it is well known that the MR signals change significantly with fixation. This is important for interpreting signals from fixed tissue and making comparisons with in vivo data. Additionally we have begun to examine the effect of temperature on the diffusion curves, measuring temperature dependant changes in the ADC and exchange rate as determined by our models.
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