This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The ability to sense and respond to the environment is a primary requirement of any living organism. We are interested in the biophysical mechanisms that allow organisms to monitor energy in their surroundings. Specifically, we are studying proteins involved in mammalian circadian clocks. In these systems, light or reducing energy is trapped by cofactors within sensory proteins. Through unknown mechanisms this captured energy is transduced to the production of new interactions among response proteins within the cell.
We aim to determine structures of sensory proteins in different redox states and in association with target response proteins. We also intend to characterize electron transfer mechanisms that allow energy conversion among components of signaling pathways.
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