Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Several major challenges for proteome informatics are associated with managing, processing, and sharing proteomics data. This subproject has two components: the extensive, open source proteome data management environment, PRIME and improved statistical and computational tools for analysis of MSMS spectra. Each of these represents a major project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR018627-05
Application #
7602901
Study Section
Special Emphasis Panel (ZRG1-BECM (40))
Project Start
2007-08-01
Project End
2008-07-31
Budget Start
2007-08-01
Budget End
2008-07-31
Support Year
5
Fiscal Year
2007
Total Cost
$93,054
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Biochemistry
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Hagen, Susan E; Liu, Kun; Jin, Yafei et al. (2018) Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry. Org Biomol Chem 16:8245-8248
Pai, Dave A; Kaplan, Craig D; Kweon, Hye Kyong et al. (2014) RNAs nonspecifically inhibit RNA polymerase II by preventing binding to the DNA template. RNA 20:644-55
Zhang, Chunchao; Gao, Shan; Molascon, Anthony J et al. (2014) Bioinformatic and proteomic analysis of bulk histones reveals PTM crosstalk and chromatin features. J Proteome Res 13:3330-7
Johnson, Cole; Kweon, Hye Kyong; Sheidy, Daniel et al. (2014) The yeast Sks1p kinase signaling network regulates pseudohyphal growth and glucose response. PLoS Genet 10:e1004183
Zhang, Chunchao; Gao, Shan; Molascon, Anthony J et al. (2014) Quantitative proteomics reveals histone modifications in crosstalk with H3 lysine 27 methylation. Mol Cell Proteomics 13:749-59
Zhang, Yan; Kweon, Hye Kyong; Shively, Christian et al. (2013) Towards systematic discovery of signaling networks in budding yeast filamentous growth stress response using interventional phosphorylation data. PLoS Comput Biol 9:e1003077
Simon, E S; Papoulias, P G; Andrews, P C (2013) Selective collision-induced fragmentation of ortho-hydroxybenzyl-aminated lysyl-containing tryptic peptides. Rapid Commun Mass Spectrom 27:1619-30
Zhang, Chunchao; Molascon, Anthony J; Gao, Shan et al. (2013) Quantitative proteomics reveals that the specific methyltransferases Txr1p and Ezl2p differentially affect the mono-, di- and trimethylation states of histone H3 lysine 27 (H3K27). Mol Cell Proteomics 12:1678-88
Gao, Shan; Xiong, Jie; Zhang, Chunchao et al. (2013) Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes Dev 27:1662-79
Zhang, Chunchao; Liu, Yifan; Andrews, Philip C (2013) Quantification of histone modifications using ยน?N metabolic labeling. Methods 61:236-43

Showing the most recent 10 out of 56 publications