There remains a compelling need for improved ways to detect and quantify toxic and/or hazardous chemical species found at existing or potential Superfund sites. Better analytical techniques could reduce the cost of monitoring, help improve remediation methods, and more accurately assess the health risks associated with hazardous and toxic species. We have developed methods to produce novel nanoparticles, arrays, and structures that could be used for chemical analysis, and propose here several approaches that combine evolving methods with the characterization and monitoring needs of Superfund. They are linked by their use of small scale properties to develop new methods that should be faster, easier, smaller, and/or less expensive. The technologies on which we will focus could ultimately lead to a number of nanometer-based devices which are portable and robust, and which can be employed at commercial facilities or in-the-field for environmental monitoring.
Our specific aims are to : 1. Develop low-cost sensors and sensor arrays for measuring chemical species such as arsenic and mercury using nanoparticle properties that can be probed optically and electronically. 2. Develop methods to identify biomolecules (specific antibodies/antigens used in bioremediation) by probing their unique local electronic structure using electron tunneling. 3. Investigate the use of new manufactured nanostructured materials for molecular detection, including structures such as carbon nanotubes and coated nanoparticles.
The aims are divided into four tasks: Gas Phase Detection of Heavy Metals Using Nanoparticle Complexes with Laser Fragmentation Spectroscopy, Mercury Detection with Gold Nanoparticles, Surface Enhanced Raman Spectroscopy Detection of Arsenic Species, and the Detection of Bioremediation Organisms using Electronic Cell Typing. This project will investigate using the different and sometimes unique behavior of materials as their size shrink below 100 nm to develop new methods to detect chemical and biological species found at existing or potential Superfund sites. New sensors could reduce the cost of monitoring, help improve remediation methods, and more accurately assess the health risks associated with hazardous and toxic species.
| Smith, Allan H; Marshall, Guillermo; Roh, Taehyun et al. (2018) Lung, Bladder, and Kidney Cancer Mortality 40?Years After Arsenic Exposure Reduction. J Natl Cancer Inst 110:241-249 |
| Castriota, Felicia; Acevedo, Johanna; Ferreccio, Catterina et al. (2018) Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile. Environ Res 167:248-254 |
| Rothman, Nathaniel; Zhang, Luoping; Smith, Martyn T et al. (2018) Formaldehyde, Hematotoxicity, and Chromosomal Changes-Response. Cancer Epidemiol Biomarkers Prev 27:120-121 |
| Yik-Sham Chung, Clive; Timblin, Greg A; Saijo, Kaoru et al. (2018) Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining. J Am Chem Soc 140:6109-6121 |
| Rappaport, Stephen M (2018) Redefining environmental exposure for disease etiology. NPJ Syst Biol Appl 4:30 |
| Tachachartvanich, Phum; Sangsuwan, Rapeepat; Ruiz, Heather S et al. (2018) Assessment of the Endocrine-Disrupting Effects of Trichloroethylene and Its Metabolites Using in Vitro and in Silico Approaches. Environ Sci Technol 52:1542-1550 |
| Guyton, Kathryn Z; Rieswijk, Linda; Wang, Amy et al. (2018) Key Characteristics Approach to Carcinogenic Hazard Identification. Chem Res Toxicol : |
| Roh, Taehyun; Steinmaus, Craig; Marshall, Guillermo et al. (2018) Age at Exposure to Arsenic in Water and Mortality 30-40 Years After Exposure Cessation. Am J Epidemiol 187:2297-2305 |
| Daniels, Sarah I; Chambers, John C; Sanchez, Sylvia S et al. (2018) Elevated Levels of Organochlorine Pesticides in South Asian Immigrants Are Associated With an Increased Risk of Diabetes. J Endocr Soc 2:832-841 |
| Guyton, Kathryn Z; Rusyn, Ivan; Chiu, Weihsueh A et al. (2018) Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis 39:614-622 |
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