The unique properties of smectite clays that are important in designing effective adsorbents and catalysts are (1) high surface area (2) high cation exchange capacity (3) swelling properties of the clay platelets and (4) high surface acidity and reactivity. Such properties make these materials inherently reactive and allows tremendous synthetic versatility to produce structures have specific properties for detoxication. Our goal is to develop a new class of materials useful for treating liquid wastes in which the contaminant is first immobilized on the clay material and then detoxified via catalysis on the clay surface. The clay-based materials being developed for this purpose are (1) transition metal saturated clays (2) organo-metal-clays (3) piliared clays and (4) delaminated clays. An additional objective is to develop and use organo- clays as components of clay barriers (e.g., bentonite slurry walls) to improve the containment characteristics of waste disposal reservoirs. Metal clays are versatile catalysts which can be used to form reactive radical cations of organic toxicants such as TCE, benzene, dioxins and phenols. These reactive radical species are subject of a variety of potential reactions to form less toxic products. Important reactions such as polymerization and dechlorination have been achieved. Organic cations can also be placed on the surface of smectite clays to impart hydrophobic properties important for adsorption of trace organic contaminants from aqueous streams. The desired sorptive and catalytic properties can be combined by using a mixture of organic and metallic cations. Pillared and delaminated clays are microporous to macroporous derivatives formed by the reaction of natural clays with robust polyoxocations. The relatively large pore sizes of these clays make them ideal adsorbents for large chlorinated hydrocarbons. Also, metal catalysts can be introduced into their structures to facilitate subsequent oxidation of the adsorbed toxicant.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Michigan State University
Department
Type
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Zhang, Qiang; Li, Jin; Middleton, Alistair et al. (2018) Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling. Front Public Health 6:261
Fader, K A; Nault, R; Kirby, M P et al. (2018) Corrigendum to ""Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERB?/? activation in aryl hydrocarbon receptor-elicited hepatotoxicity"" [Toxicol. Appl. Pharmacol. 321 (2017) 1-17]. Toxicol Appl Pharmacol 344:74
Konganti, Kranti; Ehrlich, Andre; Rusyn, Ivan et al. (2018) gQTL: A Web Application for QTL Analysis Using the Collaborative Cross Mouse Genetic Reference Population. G3 (Bethesda) 8:2559-2562
Zhang, Shuai; Liu, Qinfu; Gao, Feng et al. (2018) Molecular Dynamics Simulation of Basal Spacing, Energetics, and Structure Evolution of a Kaolinite-Formamide Intercalation Complex and Their Interfacial Interaction. J Phys Chem C Nanomater Interfaces 122:3341-3349
Nault, Rance; Doskey, Claire M; Fader, Kelly A et al. (2018) Comparison of Hepatic NRF2 and Aryl Hydrocarbon Receptor Binding in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Treated Mice Demonstrates NRF2-Independent PKM2 Induction. Mol Pharmacol 94:876-884
Dornbos, Peter; LaPres, John J (2018) Incorporating population-level genetic variability within laboratory models in toxicology: From the individual to the population. Toxicology 395:1-8
Zhang, Shuai; Liu, Qinfu; Gao, Feng et al. (2018) Interfacial Structure and Interaction of Kaolinite Intercalated with N-methylformamide Insight from Molecular Dynamics Modeling. Appl Clay Sci 158:204-210
Fader, Kelly A; Nault, Rance; Raehtz, Sandi et al. (2018) 2,3,7,8-Tetrachlorodibenzo-p-dioxin dose-dependently increases bone mass and decreases marrow adiposity in juvenile mice. Toxicol Appl Pharmacol 348:85-98
Zhang, Shuai; Liu, Qinfu; Cheng, Hongfei et al. (2018) Mechanism Responsible for Intercalation of Dimethyl Sulfoxide in Kaolinite: Molecular Dynamics Simulations. Appl Clay Sci 151:46-53
Williams, M R; Stedtfeld, R D; Waseem, H et al. (2017) Implications of direct amplification for measuring antimicrobial resistance using point-of-care devices. Anal Methods 9:1229-1241

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