The Mohawk people of Akwesasne live in an area of high environmental pollution which appears to be affecting their diet, economy and way of life. Known high levels of polychlorinated biphenyls (PCBs) are believed to be affecting their physical and psychological well-being. The primary purpose of this study is to examine the extent to which exposure to PCBs as determined by body burden levels and perceived impact of the exposure, affect cultural identity and practices, neuropsychological functioning and quality of life. The study will also examine the extent to which these factors are related to depression and psychological distress.
The specific aims are: (1) to examine the relationships among PCB exposure, major depression, and depressive symptoms; (2) to examine the relationships among PCB exposure, neuropsychological functioning, depression, and depressive symptoms; (3) to examine the relationships among PCB exposure, thyroid functioning, neuropsychological functioning and depression; (4) to examine the extent to which cultural practices have been altered as a result of exposure to PCBs; (5) to examine the relationships among quality of life factors, depression and depressive symptoms, and neuropsychological function; (6) to examine the extent to which major life events and their perceived impact are related to depression and depressive symptoms; (7) to examine the extent to which cultural identification and practices are predisposing vulnerability factors or buffers against the adverse effects of exposure to PCBs; and (8) to determine the most effective way of disseminating research findings to the community and assist in developing community outreach interventions.

Project Start
1999-04-01
Project End
2002-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost
Name
State University of New York at Albany
Department
Type
DUNS #
City
Albany
State
NY
Country
United States
Zip Code
12222
Aminov, Zafar; Haase, Richard; Rej, Robert et al. (2016) Diabetes Prevalence in Relation to Serum Concentrations of Polychlorinated Biphenyl (PCB) Congener Groups and Three Chlorinated Pesticides in a Native American Population. Environ Health Perspect 124:1376-83
Schell, Lawrence M; Gallo, Mia V (2012) Overweight and obesity among North American Indian infants, children, and youth. Am J Hum Biol 24:302-13
Schell, Lawrence M; Burnitz, Kristopher K; Gallo, Mia V (2012) Growth as a mirror: is endocrine disruption challenging Tanner's concept? Ann Hum Biol 39:361-71
Schell, Lawrence M; Gallo, Mia V; Cook, Katsi (2012) What's NOT to eat--food adulteration in the context of human biology. Am J Hum Biol 24:139-48
Schell, Lawrence M; Gallo, Mia V (2010) Relationships of putative endocrine disruptors to human sexual maturation and thyroid activity in youth. Physiol Behav 99:246-53
Haase, Richard F; McCaffrey, Robert J; Santiago-Rivera, Azara L et al. (2009) Evidence of an age-related threshold effect of polychlorinated biphenyls (PCBs) on neuropsychological functioning in a Native American population. Environ Res 109:73-85
Schell, Lawrence M; Gallo, Mia V; Ravenscroft, Julia et al. (2009) Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne Mohawk young adults. Environ Res 109:86-92
Goncharov, Alexey; Rej, Robert; Negoita, Serban et al. (2009) Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men. Environ Health Perspect 117:1454-60
Ye, Xibiao; Fitzgerald, Edward F; Gomez, Marta I et al. (2008) The ratio of specific polychlorinated biphenyls as a surrogate biomarker of cytochrome P4501A2 activity: a pharmaco-metabonomic study in humans. Cancer Epidemiol Biomarkers Prev 17:1013-5
Kim, Jongseol; Cho, Young-Cheol; Frohnhoefer, Robert C et al. (2008) Dechlorination of individual congeners in aroclor 1248 as enhanced by chlorobenzoates, chlorophenols, and chlorobenzenes. J Microbiol Biotechnol 18:1701-8

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