The laboratory Services Core will be concerned with three series of analysis, PCB, endocrine, and metals, also with the care and dosing of pregnant rats precisely-timed which will be employed by the four biomedical projects. PCB analysis will be by gas chromatography with electron capture detection using two capillary columns a silicone stationary phase (Ultra II) and an hydrocarbon stationary phase (Apiezon L); the latter will be used for peak confirmation. Human serum will be the commonest analytical matrix, experimental animal tissues, water, air and dust will also be analyzed for PCB, selected samples will be analyzed for 12 coplanar and semicoplanar PCB after Hypercarb HPLC separation and for PCDF's after further clean up using mass spectrometry. Endocrine analysis will be undertaken by standard RIA tests on human samples and by modified immunological tests for animals. Lead, organic and inorganic mercury and fluoride will be determined in children's samples by atomic absorption spectroscopy and ion selective electrode by the Centre de Toxicologie du Quebec under contract. Pregnant precisely-timed rats will be obtained from a reliable supplier and dosed with Aroclor 1248, the pollutant at Akwesasne and four individual PCB congeners representing various classes of PCB with differing biologic activity, namely; 2,4,4'-trichlorobiphenyl (#28)2,4,5,3',4'- pentachlorobiphenyl(#118) 3,4,5,3',4'-pentachlorobiphenyl(#126) 2,4,5,2',4',5'-hexachlorobiphenyl(#153). These dams and their pups will be used for different experiments in Projects 3-6. Novel organic chemical analysis will be provided using GC/FTIR/MS high resolution mass spectrometry and HPLC/CI/MS for metabolites and degradation products derived from the 4 biomedical and three degradation projects. This core project will involve a large amount of data collation and preliminary assembly in service of both Core B and the other 10 projects.

Project Start
1999-04-01
Project End
2002-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
2000
Total Cost
$230,840
Indirect Cost
Name
State University of New York at Albany
Department
Type
DUNS #
152652822
City
Albany
State
NY
Country
United States
Zip Code
12222
Aminov, Zafar; Haase, Richard; Rej, Robert et al. (2016) Diabetes Prevalence in Relation to Serum Concentrations of Polychlorinated Biphenyl (PCB) Congener Groups and Three Chlorinated Pesticides in a Native American Population. Environ Health Perspect 124:1376-83
Schell, Lawrence M; Gallo, Mia V (2012) Overweight and obesity among North American Indian infants, children, and youth. Am J Hum Biol 24:302-13
Schell, Lawrence M; Burnitz, Kristopher K; Gallo, Mia V (2012) Growth as a mirror: is endocrine disruption challenging Tanner's concept? Ann Hum Biol 39:361-71
Schell, Lawrence M; Gallo, Mia V; Cook, Katsi (2012) What's NOT to eat--food adulteration in the context of human biology. Am J Hum Biol 24:139-48
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Haase, Richard F; McCaffrey, Robert J; Santiago-Rivera, Azara L et al. (2009) Evidence of an age-related threshold effect of polychlorinated biphenyls (PCBs) on neuropsychological functioning in a Native American population. Environ Res 109:73-85
Schell, Lawrence M; Gallo, Mia V; Ravenscroft, Julia et al. (2009) Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne Mohawk young adults. Environ Res 109:86-92
Goncharov, Alexey; Rej, Robert; Negoita, Serban et al. (2009) Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men. Environ Health Perspect 117:1454-60
Ye, Xibiao; Fitzgerald, Edward F; Gomez, Marta I et al. (2008) The ratio of specific polychlorinated biphenyls as a surrogate biomarker of cytochrome P4501A2 activity: a pharmaco-metabonomic study in humans. Cancer Epidemiol Biomarkers Prev 17:1013-5
Kim, Jongseol; Cho, Young-Cheol; Frohnhoefer, Robert C et al. (2008) Dechlorination of individual congeners in aroclor 1248 as enhanced by chlorobenzoates, chlorophenols, and chlorobenzenes. J Microbiol Biotechnol 18:1701-8

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