Abstract

The investigators propose to examine the interactive accumulation, toxicity, and excretion of Hg, Cd, As, and Cr in rabbit kidney slices and in primary cultures of proximal renal tubular cells grown on porous membrane supports.
The aim i s to determine the effect of exposure to one metal on the kinetics and toxicity of the other metals, using in vitro systems and based on micro-PIXE analyses and biochemical indices of toxicity (e.g., K+/DNA ratio). The effects of certain metal ligands (GSH, MT, albumin) and chelators (DMPS) on the interactions will be tested.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES004940-10
Application #
6106238
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
10
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Simon-Pascual, Alvaro; Sierra-Alvarez, Reyes; Ramos-Ruiz, Adriana et al. (2018) Reduction of platinum (IV) ions to elemental platinum nanoparticles by anaerobic sludge. J Chem Technol Biotechnol 93:1611-1617
Lyu, Ying; Brusseau, Mark L; Chen, Wei et al. (2018) Adsorption of PFOA at the Air-Water Interface during Transport in Unsaturated Porous Media. Environ Sci Technol 52:7745-7753
Zeng, Chao; Nguyen, Chi; Boitano, Scott et al. (2018) Cerium dioxide (CeO2) nanoparticles decrease arsenite (As(III)) cytotoxicity to 16HBE14o- human bronchial epithelial cells. Environ Res 164:452-458
Zeb, Bahadar; Alam, Khan; Sorooshian, Armin et al. (2018) On the Morphology and Composition of Particulate Matter in an Urban Environment. Aerosol Air Qual Res 18:1431-1447
Khan, Muhammad Amjad; Ding, Xiaodong; Khan, Sardar et al. (2018) The influence of various organic amendments on the bioavailability and plant uptake of cadmium present in mine-degraded soil. Sci Total Environ 636:810-817
Yellowhair, Monica; Romanotto, Michelle R; Stearns, Diane M et al. (2018) Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38
Fu, Xiaori; Dionysiou, Dionysios D; Brusseau, Mark L et al. (2018) Enhanced effect of EDDS and hydroxylamine on Fe(II)-catalyzed SPC system for trichloroethylene degradation. Environ Sci Pollut Res Int 25:15733-15742
Duncan, Candice M; Brusseau, Mark L (2018) An assessment of correlations between chlorinated VOC concentrations in tree tissue and groundwater for phytoscreening applications. Sci Total Environ 616-617:875-880
Virgone, K M; Ramirez-Andreotta, M; Mainhagu, J et al. (2018) Effective integrated frameworks for assessing mining sustainability. Environ Geochem Health 40:2635-2655
Namdari, Soodabeh; Karimi, Neamat; Sorooshian, Armin et al. (2018) Impacts of climate and synoptic fluctuations on dust storm activity over the Middle East. Atmos Environ (1994) 173:265-276

Showing the most recent 10 out of 497 publications