The theme of our Superfund Basic Research Program continues the achievements of the previous grant which is to develop a risk assessment process for metal and organic contaminants through toxicologic and hydrogeologic studies and through development of innovative remediation technologies. Our application Southwestern hazardous through development of innovative remediation technologies. Our application emphasizes Southwestern hazardous waste issue due to the unique nature of our environment. However, our studies are not limited to the Southwest since the main toxicants being examined, arsenic and chlorinated hydrocarbons, are not unique to the Southwest and our results can be applied to other hazardous waste sites. Our Program consists of 10 research projects-four (4) biomedical projects and six (6) environmental sciences projects. These are supported by 5 Cores that: administer the Program, provide research services promote outreach efforts, and support graduate student training. Our Program culminates in a Community Based Prevention/Intervention Research Project, which addresses an immediate and important environmental health problem and draws on the expertise of our Program, governmental agencies, and the community at risk to handle this environmental issue. The goal of the Biomedical research projects is to determine the fate and processing of arsenic in the body and the effects of low level arsenic exposure on target tissues-skin, kidney, and developing tissues. A continuing goal is to determine the mechanism of trichloroethylene (TCE)-induced effects on the developing tissues. A continuing goal is to determine the mechanism of trichloroethylene (TCE)-induce defects on the developing heart. One component of our studies in environmental sciences is to develop better hydrogeological models of mine wastes and develop approaches for treating this waste. A group of our environmental research projects will develop better methods to improve the removal of complex mixtures from the soils and underground waters of our Southwestern environment and use improved biological techniques (e.g. biosurfactants and gene-augmented microbes) to degrade the hazardous wastes. Finally, our chemists and bioengineers and bioengineers will develop improved, innovative technologies (both chemical and physical) for the treatment and degradation of halogenated organics . Our Program is an integrated effort to address the hazardous waste issues of our region, translate the results to our partners (government, industry, and the community), and fulfill the mandates of the national SBRP Program.
| Zeng, Chao; Nguyen, Chi; Boitano, Scott et al. (2018) Cerium dioxide (CeO2) nanoparticles decrease arsenite (As(III)) cytotoxicity to 16HBE14o- human bronchial epithelial cells. Environ Res 164:452-458 |
| Zeb, Bahadar; Alam, Khan; Sorooshian, Armin et al. (2018) On the Morphology and Composition of Particulate Matter in an Urban Environment. Aerosol Air Qual Res 18:1431-1447 |
| Khan, Muhammad Amjad; Ding, Xiaodong; Khan, Sardar et al. (2018) The influence of various organic amendments on the bioavailability and plant uptake of cadmium present in mine-degraded soil. Sci Total Environ 636:810-817 |
| Yellowhair, Monica; Romanotto, Michelle R; Stearns, Diane M et al. (2018) Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38 |
| Fu, Xiaori; Dionysiou, Dionysios D; Brusseau, Mark L et al. (2018) Enhanced effect of EDDS and hydroxylamine on Fe(II)-catalyzed SPC system for trichloroethylene degradation. Environ Sci Pollut Res Int 25:15733-15742 |
| Duncan, Candice M; Brusseau, Mark L (2018) An assessment of correlations between chlorinated VOC concentrations in tree tissue and groundwater for phytoscreening applications. Sci Total Environ 616-617:875-880 |
| Virgone, K M; Ramirez-Andreotta, M; Mainhagu, J et al. (2018) Effective integrated frameworks for assessing mining sustainability. Environ Geochem Health 40:2635-2655 |
| Namdari, Soodabeh; Karimi, Neamat; Sorooshian, Armin et al. (2018) Impacts of climate and synoptic fluctuations on dust storm activity over the Middle East. Atmos Environ (1994) 173:265-276 |
| Hossein Mardi, Ali; Khaghani, Ali; MacDonald, Alexander B et al. (2018) The Lake Urmia environmental disaster in Iran: A look at aerosol pollution. Sci Total Environ 633:42-49 |
| Dehghani, Mansooreh; Fazlzadeh, Mehdi; Sorooshian, Armin et al. (2018) Characteristics and health effects of BTEX in a hot spot for urban pollution. Ecotoxicol Environ Saf 155:133-143 |
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