Epidemiological studies have confirmed that inorganic arsenic is a human carcinogen. It is clear that the complex biotransformation pathways of arsenic undergoes produces several chemical forms of arsenic that vary greatly in their toxicological potency. Thus, it is reasonable to expect that human biotransformation of arsenic is key to its toxic effects. Arsenic biotransformation appears to have a considerable degree of inter-individual variability that has the characteristics of being heritably determined, suggested by a number of studies, including reports of familial aggregation of urinary arsenic metabolite levels. Thus, understanding the metabolism of arsenic is a prerequisite to understanding its toxicological effects in humans. This project will fully characterize the genetic variability of all known genes involved in arsenic biotransformation in a diverse group of ethnically defined, globally collected human samples of arsenic-exposed individuals. Within these populations we will conduct what we believe to be the largest genetic association study to date, with the aim of relating individual variation in arsenic metabolism, measured in two complementary ways-enzymatic activity and urinary metabolite levels, to variations in the DNA sequence of candidate genes involved in arsenic metabolism, including GSTO1-1, PNP, and CYT19. Subsequent Aims will be directed at expressing variant isoforms of candidate gene products and characterizing their biochemical activity to complement the genetic associations with mechanistic information. Finally, this project will continue the group's past success in efforts to identify new arsenic biotransformation pathway members. The successful completion of this work will provide one of the most comprehensive data sets describing the human biotransformation of arsenic, and will be a valuable resource to the scientific community, as well as the general community of stakeholders in the SBRP program.
| Zeng, Chao; Nguyen, Chi; Boitano, Scott et al. (2018) Cerium dioxide (CeO2) nanoparticles decrease arsenite (As(III)) cytotoxicity to 16HBE14o- human bronchial epithelial cells. Environ Res 164:452-458 |
| Zeb, Bahadar; Alam, Khan; Sorooshian, Armin et al. (2018) On the Morphology and Composition of Particulate Matter in an Urban Environment. Aerosol Air Qual Res 18:1431-1447 |
| Khan, Muhammad Amjad; Ding, Xiaodong; Khan, Sardar et al. (2018) The influence of various organic amendments on the bioavailability and plant uptake of cadmium present in mine-degraded soil. Sci Total Environ 636:810-817 |
| Yellowhair, Monica; Romanotto, Michelle R; Stearns, Diane M et al. (2018) Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38 |
| Fu, Xiaori; Dionysiou, Dionysios D; Brusseau, Mark L et al. (2018) Enhanced effect of EDDS and hydroxylamine on Fe(II)-catalyzed SPC system for trichloroethylene degradation. Environ Sci Pollut Res Int 25:15733-15742 |
| Duncan, Candice M; Brusseau, Mark L (2018) An assessment of correlations between chlorinated VOC concentrations in tree tissue and groundwater for phytoscreening applications. Sci Total Environ 616-617:875-880 |
| Virgone, K M; Ramirez-Andreotta, M; Mainhagu, J et al. (2018) Effective integrated frameworks for assessing mining sustainability. Environ Geochem Health 40:2635-2655 |
| Namdari, Soodabeh; Karimi, Neamat; Sorooshian, Armin et al. (2018) Impacts of climate and synoptic fluctuations on dust storm activity over the Middle East. Atmos Environ (1994) 173:265-276 |
| Hossein Mardi, Ali; Khaghani, Ali; MacDonald, Alexander B et al. (2018) The Lake Urmia environmental disaster in Iran: A look at aerosol pollution. Sci Total Environ 633:42-49 |
| Dehghani, Mansooreh; Fazlzadeh, Mehdi; Sorooshian, Armin et al. (2018) Characteristics and health effects of BTEX in a hot spot for urban pollution. Ecotoxicol Environ Saf 155:133-143 |
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