(Overall Center: Maier, Lantz) The University of Arizona Superfund Research Program (UA SRP) is investigating the human and environmental risks associated with metal mining. A majority of metal mining takes place in the Western United States and other arid and semi-arid parts of the world. A central challenge for arid environments is that human exposure routes and the fate and cleanup of mining contamination are different than for areas that receive more rainfall. This has led to a large knowledge gap in regard to health and environmental effects of mine waste systems. Our Center will address two major issues within this overall gap. The first is the lack of understanding of mining waste behavior and containment and the relative impacts of airborne and waterborne spread of mine waste into arid environments. Mine wastes, in particular legacy mine tailings, generate dust- borne toxic metals (for example, arsenic and lead). These wastes also generate acid mine drainage, resulting in contamination of groundwater which is often the primary potable water source for surrounding communities. The second knowledge gap is a lack of understanding of the human health consequences of inhalation of mine dusts, specifically regarding the development of chronic lung diseases. The UA SRP has an unparalleled group of scientists to address these knowledge gaps. The three UA SRP environmental projects are focused on developing new technologies for site cleanup and on characterizing surface (dust) and subsurface (water) transport and fate of metals associated with mining waste both before and after cleanup. The two biomedical projects center around defining the importance of inhalation exposures and health impacts of metal toxicants in mine wastes, focusing on arsenic and its effects on lung disease. Results will be used to build conceptual and quantitative models to describe mechanisms of metal toxicity and movement from waste areas into neighboring communities or ecosystems. Together, our environmental and biomedical researchers will use these models to: 1) develop exposure assessment tools that can be used to evaluate the risk for communities that neighbor mine waste or smelter sites; 2) evaluate the effectiveness of new surface and subsurface cleanup technologies; and 3) provide critical information on how arsenic, one of the most prevalent toxicants in mine waste, exerts its effects. Project teams work seamlessly with Research Translation, Community Engagement, and Training Cores to support the dynamic translation of this research to communities adjacent to Superfund sites, federal (EPA, ATSDR) and state (AZ Dept. Environmental Quality, AZ Dept. Health Services) stakeholders, and the mining industry. To further its impact, the UA SRP will continue to develop complementary initiatives, such as the Center for Environmentally Sustainable Mining, an industry-academic cooperative to move research results into the field in real time. The principle guiding the UA SRP is that its research should be innovative in advancing individual scientific fields. More importantly, it should transform industry-wide practices in mining to improve environment/ecosystem preservation and protect human health.

Public Health Relevance

(Overall Center: Maier, Lantz) Human and environmental health risks associated with metal mining in arid environments are not presently well defined. The University of Arizona Superfund Research Program will work with relevant stakeholders (e.g., EPA, ATSDR, as well as state, tribal and local regulatory agencies, the mining industry and communities, as appropriate) to define these risks and develop innovative, cost-effective, long-term, evidence- based solutions that can effect change in current practices in the mining industry for the protection of human health and the environment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES004940-29S1
Application #
9693955
Study Section
Special Emphasis Panel (ZES1)
Program Officer
Carlin, Danielle J
Project Start
1997-04-01
Project End
2020-03-31
Budget Start
2018-05-04
Budget End
2019-03-31
Support Year
29
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Arizona
Department
Miscellaneous
Type
Earth Sciences/Resources
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Pu, Mengjie; Guan, Zeyu; Ma, Yongwen et al. (2018) Synthesis of iron-based metal-organic framework MIL-53 as an efficient catalyst to activate persulfate for the degradation of Orange G in aqueous solution. Appl Catal A Gen 549:82-92
Brusseau, Mark L; Guo, Zhilin (2018) The integrated contaminant elution and tracer test toolkit, ICET3, for improved characterization of mass transfer, attenuation, and mass removal. J Contam Hydrol 208:17-26
Valentín-Vargas, Alexis; Neilson, Julia W; Root, Robert A et al. (2018) Treatment impacts on temporal microbial community dynamics during phytostabilization of acid-generating mine tailings in semiarid regions. Sci Total Environ 618:357-368
Brusseau, Mark L (2018) Assessing the potential contributions of additional retention processes to PFAS retardation in the subsurface. Sci Total Environ 613-614:176-185
Delikhoon, Mahdieh; Fazlzadeh, Mehdi; Sorooshian, Armin et al. (2018) Characteristics and health effects of formaldehyde and acetaldehyde in an urban area in Iran. Environ Pollut 242:938-951
Hammond, Corin M; Root, Robert A; Maier, Raina M et al. (2018) Mechanisms of Arsenic Sequestration by Prosopis juliflora during the Phytostabilization of Metalliferous Mine Tailings. Environ Sci Technol 52:1156-1164
Yan, Ni; Zhong, Hua; Brusseau, Mark L (2018) The natural activation ability of subsurface media to promote in-situ chemical oxidation of 1,4-dioxane. Water Res 149:386-393
Madeira, Camila L; Field, Jim A; Simonich, Michael T et al. (2018) Ecotoxicity of the insensitive munitions compound 3-nitro-1,2,4-triazol-5-one (NTO) and its reduced metabolite 3-amino-1,2,4-triazol-5-one (ATO). J Hazard Mater 343:340-346
Liu, Pengfei; Rojo de la Vega, Montserrat; Sammani, Saad et al. (2018) RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A 115:E10352-E10361
Thomas, Andrew N; Root, Robert A; Lantz, R Clark et al. (2018) Oxidative weathering decreases bioaccessibility of toxic metal(loid)s in PM10 emissions from sulfide mine tailings. Geohealth 2:118-138

Showing the most recent 10 out of 497 publications