The primary objective of the Superfund Basic Research Program is to understand the human health and environmental effects associated with hazardous waste sites, and ultimately to devise strategies for remediating such sites in order to minimize public health concerns. The theme of this Program Project is to develop the scientific bases that are necessary to develop biologically-based risk assessments for several chemicals on the National Priorities List. This will be accomplished by (1) identifying critical mechanisms related to the induction of mutations and cancer by these chemicals, (2) establishing whether or not these mechanisms follow linear or nonlinear dose-response relationships between the high doses employed in animal studies and actual or modeled environmental exposures, (3) examining factors related to individual exposure through the use of ultrasensitive biomarkers and the development of personal monitoring devices, (4) determining if sensitive populations exist that are at greater or lesser risk to selected chemicals than the general population, (5) investigating the degradation and fate of chemicals in relevant ecosystems and determining if the products are more or less toxic than the starting materials, (6) evaluating mass transfer phenomena in heterogeneous multiphase subsurface systems and enhanced methods of remediating such systems, and (7) providing more meaningful estimates of human and ecological exposure to contaminants using stochastic analysis of flow and transport phenomena. The theme addresses many of the stated goals of the Superfund Basic Research Program. We will accomplish our task through the investigations proposed in seven research projects and five supporting cores.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES005948-07
Application #
2684419
Study Section
Special Emphasis Panel (SRC (G3))
Project Start
1992-04-01
Project End
2000-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Balik-Meisner, Michele; Truong, Lisa; Scholl, Elizabeth H et al. (2018) Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure. Environ Health Perspect 126:067010
To, Kimberly T; Fry, Rebecca C; Reif, David M (2018) Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi. BioData Min 11:10
Dalaijamts, Chimeddulam; Cichocki, Joseph A; Luo, Yu-Syuan et al. (2018) Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicol Appl Pharmacol 352:142-152
Gray, Kathleen M (2018) From Content Knowledge to Community Change: A Review of Representations of Environmental Health Literacy. Int J Environ Res Public Health 15:
Li, Gen; Jima, Dereje; Wright, Fred A et al. (2018) HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues. BMC Bioinformatics 19:95
Adebambo, Oluwadamilare A; Shea, Damian; Fry, Rebecca C (2018) Cadmium disrupts signaling of the hypoxia-inducible (HIF) and transforming growth factor (TGF-?) pathways in placental JEG-3 trophoblast cells via reactive oxygen species. Toxicol Appl Pharmacol 342:108-115
Smeester, Lisa; Fry, Rebecca C (2018) Long-Term Health Effects and Underlying Biological Mechanisms of Developmental Exposure to Arsenic. Curr Environ Health Rep 5:134-144
Luo, Yu-Syuan; Furuya, Shinji; Chiu, Weihsueh et al. (2018) Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. J Toxicol Environ Health A 81:37-52
Singleton, David R; Lee, Janice; Dickey, Allison N et al. (2018) Polyphasic characterization of four soil-derived phenanthrene-degrading Acidovorax strains and proposal of Acidovorax carolinensis sp. nov. Syst Appl Microbiol 41:460-472
Luo, Yu-Syuan; Hsieh, Nan-Hung; Soldatow, Valerie Y et al. (2018) Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains. Toxicology 409:33-43

Showing the most recent 10 out of 505 publications