During the prolonged period that many organic pollutants react in soil, they appear to become sequestered and their behavior changes. This sequestration or aging affects their susceptibility to biodegradation, extractability, and toxicity. However, the means presently do not exist to predict the extent of change in bioavailability with time for any organic compound. Hence, a study is proposed (1) to determine the properties of organic compounds and of soils that govern how aging-in soil affects bioavailability in terms of extractability, biodegradability, and toxicity; and (2) to establish the feasibility of using biodegradation and extraction methods to predict toxicity of organic compounds in soil. Plant (seed germination, root elongation), microbial (nitrification, Ames Salmonella mutant reversion), and invertebrate (acute toxicity to Eisenia foetida) toxicity tests will be employed as a suite applicable to soil-borne hazardous wastes. In addition, studies will be conducted on the mechanisms by which aging occurs, with attention to both porous and non-porous media (synthetic and natural), soil properties, and pore size, tortuosity, and distribution. Emphasis will be on some 25 14C-labeled compounds for which property- outcomes relationships and shifts in known rate and extent of biodegradability may be related to measures of toxicity and sequestration.

Project Start
1998-04-01
Project End
1999-03-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Cornell University
Department
Type
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
Smith, Donald; Strupp, Barbara J (2013) The scientific basis for chelation: animal studies and lead chelation. J Med Toxicol 9:326-38
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Stangle, Diane E; Smith, Donald R; Beaudin, Stephane A et al. (2007) Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure. Environ Health Perspect 115:201-9
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Stangle, Diane E; Strawderman, Myla S; Smith, Donald et al. (2004) Reductions in blood lead overestimate reductions in brain lead following repeated succimer regimens in a rodent model of childhood lead exposure. Environ Health Perspect 112:302-8
Driscoll, Lori L; Carroll, Jenna C; Moon, Jisook et al. (2004) Impaired sustained attention and error-induced stereotypy in the aged Ts65Dn mouse: a mouse model of Down syndrome and Alzheimer's disease. Behav Neurosci 118:1196-205
Lee, Ji-Eun; Dietert, Rodney R (2003) Developmental immunotoxicity of lead: impact on thymic function. Birth Defects Res A Clin Mol Teratol 67:861-7
Savage, Wesley K; Quimby, Fred W; DeCaprio, Anthony P (2002) Lethal and sublethal effects of polychlorinated biphenyls on Rana sylvatica tadpoles. Environ Toxicol Chem 21:168-74
Tang, Jixin; Liste, Hans-Holger; Alexander, Martin (2002) Chemical assays of availability to earthworms of polycyclic aromatic hydrocarbons in soil. Chemosphere 48:35-42

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