All the component projects of the Dartmouth SBRP engage in statistical analysis and scientific data management. The overall objective of the proposed Biostatistics and Data Management Core is to enhance program interactivity and scientific quality by providing the SBRP full access to the biostatistical expertise and data management resources at Dartmouth. The proposed projects involve in vitro and whole animal experimental protocols utilizing a number of complex and novel complex and novel bioassays (Project 1-3, Core A); population-based epidemiologic data with sophisticated biomarker measures of individual exposure and genetic markers (Project 4); and multi-level clustered sampling in ecological and geochemical surveys (Projects 6 and 7). Sound statistical methodology and data management are essential for the successful conduct of these projects. Economics of scale are achieved by sharing the support of statistical personnel, specialized software, and computing resources within the Core. In this way, projects that would not be able ordinarily to justify FTE lines for statistical personnel can still count on expert statistical resources during critical phases of the design and analysis of their experiments and studies. The Core will also develop enhanced statistical methods necessary to study the relationship between low to moderate arsenic exposures and cancer based on the use of multiple biomarkers of exposure, and will make use of unique Web-based statistical software maintained on the Core server (http://biostat.hitchcock.org/sbrp.htm).

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
3P42ES007373-08S1
Application #
6666430
Study Section
Special Emphasis Panel (ZES1)
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
$163,250
Indirect Cost
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Liu, Maodian; He, Yipeng; Baumann, Zofia et al. (2018) Traditional Tibetan Medicine Induced High Methylmercury Exposure Level and Environmental Mercury Burden in Tibet, China. Environ Sci Technol 52:8838-8847
Taylor, Vivien F; Li, Zhigang; Sayarath, Vicki et al. (2018) Author Correction: Distinct arsenic metabolites following seaweed consumption in humans. Sci Rep 8:4145
Emond, Jennifer A; Karagas, Margaret R; Baker, Emily R et al. (2018) Better Diet Quality during Pregnancy Is Associated with a Reduced Likelihood of an Infant Born Small for Gestational Age: An Analysis of the Prospective New Hampshire Birth Cohort Study. J Nutr 148:22-30
Jackson, Brian P (2018) Low level determination of gallium isotopes by ICP-QQQ. J Anal At Spectrom 33:897-900
Nachman, Keeve E; Punshon, Tracy; Rardin, Laurie et al. (2018) Opportunities and Challenges for Dietary Arsenic Intervention. Environ Health Perspect 126:84503
Koutros, Stella; Baris, Dalsu; Waddell, Richard et al. (2018) Potential effect modifiers of the arsenic-bladder cancer risk relationship. Int J Cancer 143:2640-2646
Liu, Maodian; Chen, Long; He, Yipeng et al. (2018) Impacts of farmed fish consumption and food trade on methylmercury exposure in China. Environ Int 120:333-344
Hampton, Thomas H; Jackson, Craig; Jung, Dawoon et al. (2018) Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish. Environ Sci Technol 52:8811-8821
Caito, Samuel W; Jackson, Brian P; Punshon, Tracy et al. (2018) Editor's Highlight: Variation in Methylmercury Metabolism and Elimination Status in Humans Following Fish Consumption. Toxicol Sci 161:443-453
Ricachenevsky, Felipe K; Punshon, Tracy; Lee, Sichul et al. (2018) Elemental Profiling of Rice FOX Lines Leads to Characterization of a New Zn Plasma Membrane Transporter, OsZIP7. Front Plant Sci 9:865

Showing the most recent 10 out of 372 publications