The Biometrics Core will provide the appropriate infrastructure to support for the statistical needs of the University of Florida Superfund Basic Research Program (SBRP) research projects and other cores. These needs include planning and design consultation for research investigators, assistance with the development of computer database applications, quality assurance/monitoring, statistical analysis and reporting. Both the computing resources as well as the experiences of the core director in the areas of experimental design, clinical trials, descriptive and analytic epidemiology studies will contribute to the ability of the SBRP to conduct the broad range of research described in this proposal. This core provides access to state-of-the-art computer facilities and expert biostatistical analysis. This core will also provide ongoing support with regards to design successor investigators both in the formation of research hypotheses as well as selection of the appropriate study design and analytic procedures for future studies.

Project Start
2000-04-01
Project End
2001-03-31
Budget Start
Budget End
Support Year
6
Fiscal Year
2000
Total Cost
$131,644
Indirect Cost
Name
University of Florida
Department
Type
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Mangal, Naveen; James, Margaret O; Stacpoole, Peter W et al. (2018) Model Informed Dose Optimization of Dichloroacetate for the Treatment of Congenital Lactic Acidosis in Children. J Clin Pharmacol 58:212-220
Jiang, Yu; Milavetz, Gary; James, Margaret O et al. (2017) A Mechanism-Based Pharmacokinetic Enzyme Turnover Model for Dichloroacetic Acid Autoinhibition in Rats. J Pharm Sci 106:1396-1404
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Shroads, A L; Coats, B S; McDonough, C W et al. (2015) Haplotype variations in glutathione transferase zeta 1 influence the kinetics and dynamics of chronic dichloroacetate in children. J Clin Pharmacol 55:50-5
James, Margaret O; Kleinow, Kevin M (2014) Seasonal influences on PCB retention and biotransformation in fish. Environ Sci Pollut Res Int 21:6324-33
Garcia-Reyero, Natàlia; Martyniuk, Christopher J; Kroll, Kevin J et al. (2013) Transcriptional signature of progesterone in the fathead minnow ovary (Pimephales promelas). Gen Comp Endocrinol 192:159-69
Kocerha, Jannet; Prucha, Melinda S; Kroll, Kevin J et al. (2010) Regulation of steroidogenic acute regulatory protein transcription in largemouth bass by orphan nuclear receptor signaling pathways. Endocrinology 151:341-9
Tan, Xiaobing; Yim, Sun-Young; Uppu, Prasanna et al. (2010) Enhanced bioaccumulation of dietary contaminants in catfish with exposure to the waterborne surfactant linear alkylbenzene sulfonate. Aquat Toxicol 99:300-8
Nyagode, Beatrice A; James, Margaret O; Kleinow, Kevin M (2009) Influence of dietary Coexposure to benzo(a)pyrene on the biotransformation and distribution of 14C-methoxychlor in the channel catfish (Ictalurus punctatus). Toxicol Sci 108:320-9
Rauschenberger, R Heath; Sepulveda, Maria S; Wiebe, Jon J et al. (2009) Nutrient and organochlorine pesticide concentrations in American alligator eggs and their associations with clutch viability. J Aquat Anim Health 21:249-61

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