Halogenated organic compounds, such as polychlorinated biphenyls (PCBs), polybrominated and polychlorinated diphenyl ethers (PBDEs and PCDEs) are important Superfund and environmental contaminants. Complex mixtures of these compounds can be found in the environment. The research support described in this proposal is the following list includes all initially requested organohalogen compounds, which will be made available to the individual Research Projects: PCB congeners (Project #1, #2, #3, #4, #5 and #7), hydroxylated PCB metabolites (Projects #1, #2, #4 and #7), 3,4-Arene oxides (Project #1), benzoquinone metabolites and glutathione conjugates of PCBs (Project #1), PBDE and PCDE congers (Research Project #6). These compounds will be synthesized with straightforward synthetic approaches that are well established in our laboratory. Because of our extensive synthetic experience with the synthesis of organohalogen compounds, we are able to synthesize every compound of interest.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
2P42ES007380-04
Application #
6328400
Study Section
Special Emphasis Panel (ZES1-DPB-D (G3))
Project Start
1997-04-07
Project End
2005-03-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2000
Total Cost
$142,466
Indirect Cost
Name
University of Kentucky
Department
Type
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
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Petriello, Michael C; Hoffman, Jessie B; Vsevolozhskaya, Olga et al. (2018) Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis. Environ Pollut 242:1022-1032
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Hennig, Bernhard (2017) Environmental challenges in Central and Eastern Europe. Rev Environ Health 32:1

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