The University of Kentucky, being a land grant and comprehensive institution, has a tradition of excellence in interdisciplinary research. Such an academic environment will allow study for the overall theme of our SBRP research, which focuses on the toxicology of Superfund chemicals and how health effects of exposure can be modulated by both intrinsic and extrinsic factors, namely genetics and nutrition, respectively. The investigators will integrate five biomedical and two non-biomedical projects to concentrate on chlorinated organics (e.g., polychlorinated biphenyls, trichloroethylene) as model toxins. Chlorinated organics are prevalent in most Superfund sites, including those found in Kentucky. The preliminary findings suggest that nutrition and dietary habits can markedly influence mechanisms of toxicity of the above-mentioned Superfund chemicals. Thus, a major objective of our SBRP is to explore the paradigm that nutrition can modify Superfund chemical toxicity. The investigators hypothesize that highly refined diets, i.e., diets high in fats or calories and low in fruits and vegetables (antioxidants), are associated with an observed national epidemic in chronic diseases, and that populations associated with such dietary habits are more prone to Superfund chemical insult. Biomedical projects will focus on chronic diseases such as cardiovascular disease, cancer, obesity, hypertension, and diabetes. In addition, non-biomedical projects will explore novel techniques for both remediation (detoxification) and biosensors associated with PCBs and other chlorinated organics. Results from the interdisciplinary research will be utilized for informative/educational, technology transfer, training, policy and translational purposes as part of the objectives of the Research Translation, Community Outreach, and Training Cores. Nutrition may be the most sensible means to develop primary prevention strategies of diseases associated with many environmental toxic insults. Thus, the research may lead to novel dietary recommendations at the national level for populations at risk, i.e., people residing near Superfund sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES007380-10
Application #
7067164
Study Section
Special Emphasis Panel (ZES1-JAB-A (S5))
Program Officer
Suk, William
Project Start
1997-04-07
Project End
2008-03-31
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
10
Fiscal Year
2006
Total Cost
$2,199,613
Indirect Cost
Name
University of Kentucky
Department
Veterinary Sciences
Type
Schools of Earth Sciences/Natur
DUNS #
939017877
City
Lexington
State
KY
Country
United States
Zip Code
40506
Deng, Pan; Barney, Jazmyne; Petriello, Michael C et al. (2018) Hepatic metabolomics reveals that liver injury increases PCB 126-induced oxidative stress and metabolic dysfunction. Chemosphere 217:140-149
Preston, Joshua D; Reynolds, Leryn J; Pearson, Kevin J (2018) Developmental Origins of Health Span and Life Span: A Mini-Review. Gerontology 64:237-245
Gupta, Prachi; Thompson, Brendan L; Wahlang, Banrida et al. (2018) The environmental pollutant, polychlorinated biphenyls, and cardiovascular disease: a potential target for antioxidant nanotherapeutics. Drug Deliv Transl Res 8:740-759
Roghani, Mohammadyousef; Jacobs, Olivia P; Miller, Anthony et al. (2018) Occurrence of chlorinated volatile organic compounds (VOCs) in a sanitary sewer system: Implications for assessing vapor intrusion alternative pathways. Sci Total Environ 616-617:1149-1162
Ahmad, Irfan; Weng, Jiaying; Stromberg, A J et al. (2018) Fluorescence based detection of polychlorinated biphenyls (PCBs) in water using hydrophobic interactions. Analyst :
Petriello, Michael C; Hoffman, Jessie B; Vsevolozhskaya, Olga et al. (2018) Dioxin-like PCB 126 increases intestinal inflammation and disrupts gut microbiota and metabolic homeostasis. Environ Pollut 242:1022-1032
Petriello, Michael C; Charnigo, Richard; Sunkara, Manjula et al. (2018) Relationship between serum trimethylamine N-oxide and exposure to dioxin-like pollutants. Environ Res 162:211-218
Hennig, Bernhard (2017) Environmental challenges in Central and Eastern Europe. Rev Environ Health 32:1
Wahlang, Banrida; Perkins, Jordan T; Petriello, Michael C et al. (2017) A compromised liver alters polychlorinated biphenyl-mediated toxicity. Toxicology 380:11-22
Aher, Ashish; Papp, Joseph; Colburn, Andrew et al. (2017) Naphthenic acids removal from high TDS produced water by persulfate mediated iron oxide functionalized catalytic membrane, and by nanofiltration. Chem Eng J 327:573-583

Showing the most recent 10 out of 255 publications