Tetrachloroethylene also called perchlorethylene or PCE) is a solvent commonly used for decreasing operation and as a dry cleaning agent. It is also a common contaminant in public drinking water supplies. Both epidemiological and toxicological data implicate PCE as a carcinogen. Our prior research suggests that PCE-contaminated drinking water may be associated with an increased risk of breast cancer. We conducted a population-based case-control study including 258 breast cancer cases diagnosed from 1983 through 1986. Subjects were exposed to PCE when it leached from the plastic lining of drinking water distribution pipes from the late 1960s through the 1970s. The adjusted relative risks of breast cancer among """"""""highly' exposed subjects ranged from 1.3 when latency was ignored to 2.4 when 9 years of latency was applied. However, the increased risks were not statistically significant because th proportion of exposed subjects was small, particularly when long latent periods were hypothesized. Thus, a larger case-control study of more recently diagnosed cases is needed to estimate precisely the risk for different latency assumptions. The proposed epidemiologic study will test the hypothesis that PCE found in the distribution systems of public drinking water supplies in the Cape Cod region of Massachusetts is associated with breast cancer. This will be accomplished by conducting a population-based case-control study including 1,170 cases diagnosed from 1987 through 1995 and 1,170 controls and: (1) Estimating PCE exposure in breast cancer cases and controls using a well- developed exposure model; (2) Determining the relationship between breast cancer risk and estimated PCE exposure while controlling for confounding variables; and (3) Evaluating the impact of residential water use for drinking, cooking, and bathing on the relationship between breast cancer risk and estimated PCE exposure.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Boston University
United States
Zip Code
Lille-Langøy, Roger; Karlsen, Odd André; Myklebust, Line Merethe et al. (2018) Sequence variations in pxr (nr1i2) from zebrafish (Danio rerio) strains affect nuclear receptor function. Toxicol Sci :
Lemaire, Benjamin; Karchner, Sibel I; Goldstone, Jared V et al. (2018) Molecular adaptation to high pressure in cytochrome P450 1A and aryl hydrocarbon receptor systems of the deep-sea fish Coryphaenoides armatus. Biochim Biophys Acta Proteins Proteom 1866:155-165
Eide, Marta; Rydbeck, Halfdan; Tørresen, Ole K et al. (2018) Independent losses of a xenobiotic receptor across teleost evolution. Sci Rep 8:10404
Watt, James; Baker, Amelia H; Meeks, Brett et al. (2018) Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. J Cell Physiol 233:7007-7021
Aschengrau, Ann; Gallagher, Lisa G; Winter, Michael et al. (2018) Modeled exposure to tetrachloroethylene-contaminated drinking water and the risk of placenta-related stillbirths: a case-control study from Massachusetts and Rhode Island. Environ Health 17:58
Kim, Stephanie; Li, Amy; Monti, Stefano et al. (2018) Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. Arch Toxicol 92:2859-2874
Herkert, Nicholas J; Spak, Scott N; Smith, Austen et al. (2018) Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts 20:210-219
Timme-Laragy, Alicia R; Hahn, Mark E; Hansen, Jason M et al. (2018) Redox stress and signaling during vertebrate embryonic development: Regulation and responses. Semin Cell Dev Biol 80:17-28
Glazer, Lilah; Kido Soule, Melissa C; Longnecker, Krista et al. (2018) Hepatic metabolite profiling of polychlorinated biphenyl (PCB)-resistant and sensitive populations of Atlantic killifish (Fundulus heteroclitus). Aquat Toxicol 205:114-122
Basra, Komal; Scammell, Madeleine K; Benson, Eugene B et al. (2018) Ambient Air Exposure to PCBs: Regulation and Monitoring at Five Contaminated Sites in EPA Regions 1, 2, 4, and 5. New Solut 28:262-282

Showing the most recent 10 out of 398 publications