Core - Exposure Assessment

Wolff, Mary S.

Abstract

The Exposure Assessment Core C will provide analytical support for comprehensive assessment of lead exposures in Projects 1-4. Body burden measures will include blood lead, plasma lead, ZPP, and bone lead, representing multiple compartments for deposition of lead and widely variable rates of elimination. As an adjunct to Projects 1 and 2, measurement of total lead in soil extracts will be done to validate quantitative measures obtained separately by stable isotope determinations. For Projects 5-7, an overall assessment of organic contaminants in harbor sediments is integral to ecological studies and to in vitro utilization of these samples. Extensive characterization of organochlorines will be done in Project 5, and this Core will supplement those studies by providing analyses for PAH and TCDD, compounds that are environmentally important and that may contribute significantly to the assays to be done in Projects 6-7

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Environmental Health Sciences (NIEHS)
• Type: Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
• Project #: 5P42ES007384-02
• Application #: 5211406
• Support Year: 2
• Fiscal Year: 1996

Publications

Yan, Beizhan; Bopp, Richard F; Abrajano, Teofilo A et al. (2014) Source apportionment of polycyclic aromatic hydrocarbons (PAHs) into Central Park Lake, New York City, over a century of deposition. Environ Toxicol Chem 33:985-92

Miller, Todd R; Colquhoun, David R; Halden, Rolf U (2010) Identification of wastewater bacteria involved in the degradation of triclocarban and its non-chlorinated congener. J Hazard Mater 183:766-72

Miller, Todd R; Heidler, Jochen; Chillrud, Steven N et al. (2008) Fate of triclosan and evidence for reductive dechlorination of triclocarban in estuarine sediments. Environ Sci Technol 42:4570-6

Landrigan, Philip J; Forman, Joel; Galvez, Maida et al. (2008) Impact of September 11 World Trade Center disaster on children and pregnant women. Mt Sinai J Med 75:129-34

Louchouarn, Patrick; Chillrud, Steven N; Houel, Stephane et al. (2007) Elemental and molecular evidence of soot- and char-derived black carbon inputs to New York City's atmosphere during the 20th century. Environ Sci Technol 41:82-7

Grandjean, P; Landrigan, P J (2006) Developmental neurotoxicity of industrial chemicals. Lancet 368:2167-78

Wallenstein, Sylvan; Chen, Jia; Wetmur, James G (2006) Comparison of statistical models for analyzing genotype, inferred haplotype, and molecular haplotype data. Mol Genet Metab 89:270-3

Trasande, Leonardo; Schechter, Clyde; Haynes, Karla A et al. (2006) Applying cost analyses to drive policy that protects children: mercury as a case study. Ann N Y Acad Sci 1076:911-23

Ma, Risheng; Sassoon, David A (2006) PCBs exert an estrogenic effect through repression of the Wnt7a signaling pathway in the female reproductive tract. Environ Health Perspect 114:898-904

Gobeille, Alayne K; Morland, Kimberly B; Bopp, Richard F et al. (2006) Body burdens of mercury in lower Hudson River area anglers. Environ Res 101:205-12