The Community Outreach Core is an environmental justice project involving the communication and sharing of SBRP-generated knowledge and tools with Tribal communities affected by hazardous waste sites and toxicants. The applicants will use a Tribal Regional Workbench approach to enabling equitable environmental stewardship of Indian Reservations. The broad objective is to shift the emphasis from risk assessment as a disease paradigm to risk assessment as a wellness paradigm that embraces Tribal Traditional Lifeways. This new approach is identified as a high priority by the U.S. EPA's National Tribal Science Council, the National Tribal Environmental Council (NTEC), and Tribal environmental protection agencies. They will directly collaborate with Tribal communities both locally, 1) the Campo Indian Reservation, part of the Kumeyaay Nation; 2) the Tribal environmental lab located at the Twenty-Nine Palms Band of Mission Indians, and nationally: 3) the Superfund Project Group of NTEC. These communities include prominent Tribal scientists who will help us create a unique Tribal information system that will be called the Tribal Regional Workbench (modeled after the UCSD SBRP Regional Workbench). The Tribal-RWB will be developed as a forum and an ensemble of datasets and information and knowledge integration tools to support online analysis, visualization and communication of environmental justice and quality of life issues explored within the Core's collaborative projects. The Community Outreach Core has five aims, grouped into two broad categories: Communication and Environmental Justice, and Knowledge Systems Integration.
Specific Aims i nclude 1a) to build a Tribal Regional Workbench Web site; 1b) to share SBRP-generated knowledge and tools; 2a) to host a regional gathering of tribal leaders and scientists; 2b) to facilitate training opportunities for graduate and undergraduate students; and 3c) to co-investigator a series of papers, articles, and other publications with Tribal partners.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010337-09
Application #
7598934
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
9
Fiscal Year
2008
Total Cost
$129,171
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Song, Isabelle Jingyi; Yang, Yoon Mee; Inokuchi-Shimizu, Sayaka et al. (2018) The contribution of toll-like receptor signaling to the development of liver fibrosis and cancer in hepatocyte-specific TAK1-deleted mice. Int J Cancer 142:81-91
Hoffmann, Hanne; Pandolfi, Erica; Larder, Rachel et al. (2018) Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2, Causes Subfertility in Mice Via Distinct Mechanisms. Neuroendocrinology :
Dow, Michelle; Pyke, Rachel M; Tsui, Brian Y et al. (2018) Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A 115:E9879-E9888
Kim, Ju Youn; Garcia-Carbonell, Ricard; Yamachika, Shinichiro et al. (2018) ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell 175:133-145.e15
Que, Xuchu; Hung, Ming-Yow; Yeang, Calvin et al. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301-306
Fan, Weiwei; He, Nanhai; Lin, Chun Shi et al. (2018) ERR? Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1?/?-Deficient Muscle. Cell Rep 22:2521-2529
Brouha, Sharon S; Nguyen, Phirum; Bettencourt, Ricki et al. (2018) Increased severity of liver fat content and liver fibrosis in non-alcoholic fatty liver disease correlate with epicardial fat volume in type 2 diabetes: A prospective study. Eur Radiol 28:1345-1355
Hsu, Po-Kai; Takahashi, Yohei; Munemasa, Shintaro et al. (2018) Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. Proc Natl Acad Sci U S A 115:E9971-E9980
Dhar, Debanjan; Antonucci, Laura; Nakagawa, Hayato et al. (2018) Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell 33:1061-1077.e6
Febbraio, Mark A; Reibe, Saskia; Shalapour, Shabnam et al. (2018) Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab :

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