The primary aim of the training core is to train Ph.D. candidates in medical and biological sciences relating to environmental health, especially in areas that relate to cellular signal transduction in mammalian cells. Training will interface with activities in the laboratories of participating UCSD faculty members, interests of several San Diego corporate partners in environmental sciences, screening and remediation. Students can enter the program through Biomedical Sciences, .Chemistry-Biochemistry, Scripps Institution of Oceanography, Biology, Bioengineering, and Neurosciences umbrella graduate programs. In addition to the general requirements of the admitting umbrella program, students are required to enroll and participate in several Superfund sponsored academic enrichment programs and courses.
The aims of the training program are, 1) identify students with strong interest in Environmental Health Sciences who have joined laboratories supported by the Superfund from the variety of allied graduate programs at UC San Diego; 2) provide training grant support through Superfund and Teaching Assistantships through departments to support graduate training of four candidates per year; 3) offer educational opportunities through coursework and seminars that emphasize the unique aspects of the environmental sciences program associated with Superfund;4) provide travel stipends to attend Superfund and national toxicology meetings;5) provide a strong basis for students to emerge as independent scientists with a broad range of skills and knowledge while maintaining a focus on environmental health sciences;and 6) launch the careers of Ph.D.s in the molecular investigation of toxicology, toxicogenomics, and environmental health sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Hazardous Substances Basic Research Grants Program (NIEHS) (P42)
Project #
5P42ES010337-10
Application #
7799245
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
10
Fiscal Year
2009
Total Cost
$180,371
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Hsu, Po-Kai; Takahashi, Yohei; Munemasa, Shintaro et al. (2018) Abscisic acid-independent stomatal CO2 signal transduction pathway and convergence of CO2 and ABA signaling downstream of OST1 kinase. Proc Natl Acad Sci U S A 115:E9971-E9980
Dhar, Debanjan; Antonucci, Laura; Nakagawa, Hayato et al. (2018) Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell 33:1061-1077.e6
Febbraio, Mark A; Reibe, Saskia; Shalapour, Shabnam et al. (2018) Preclinical Models for Studying NASH-Driven HCC: How Useful Are They? Cell Metab :
Fujiwara, Ryoichi; Yoda, Emiko; Tukey, Robert H (2018) Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans. Drug Metab Pharmacokinet 33:9-16
Hartmann, Phillipp; Hochrath, Katrin; Horvath, Angela et al. (2018) Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. Hepatology 67:2150-2166
Ganguly, Abantika; Guo, Lan; Sun, Lingling et al. (2018) Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks. PLoS Genet 14:e1007595
Tripathi, Anupriya; Debelius, Justine; Brenner, David A et al. (2018) The gut-liver axis and the intersection with the microbiome. Nat Rev Gastroenterol Hepatol 15:397-411
Chen, Shujuan; Tukey, Robert H (2018) Humanized UGT1 Mice, Regulation of UGT1A1, and the Role of the Intestinal Tract in Neonatal Hyperbilirubinemia and Breast Milk-Induced Jaundice. Drug Metab Dispos 46:1745-1755
Desai, Archita P; Mohan, Prashanthinie; Roubal, Anne M et al. (2018) Geographic Variability in Liver Disease-Related Mortality Rates in the United States. Am J Med 131:728-734
Ajmera, Veeral; Park, Charlie C; Caussy, Cyrielle et al. (2018) Magnetic Resonance Imaging Proton Density Fat Fraction Associates With Progression of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease. Gastroenterology 155:307-310.e2

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